Document Detail


Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network.
MedLine Citation:
PMID:  20732945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This report presents data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network on care of and morbidity and mortality rates for very low birth weight infants, according to gestational age (GA).
METHODS: Perinatal/neonatal data were collected for 9575 infants of extremely low GA (22-28 weeks) and very low birth weight (401-1500 g) who were born at network centers between January 1, 2003, and December 31, 2007.
RESULTS: Rates of survival to discharge increased with increasing GA (6% at 22 weeks and 92% at 28 weeks); 1060 infants died at <or=12 hours, with most early deaths occurring at 22 and 23 weeks (85% and 43%, respectively). Rates of prenatal steroid use (13% and 53%, respectively), cesarean section (7% and 24%, respectively), and delivery room intubation (19% and 68%, respectively) increased markedly between 22 and 23 weeks. Infants at the lowest GAs were at greatest risk for morbidities. Overall, 93% had respiratory distress syndrome, 46% patent ductus arteriosus, 16% severe intraventricular hemorrhage, 11% necrotizing enterocolitis, and 36% late-onset sepsis. The new severity-based definition of bronchopulmonary dysplasia classified more infants as having bronchopulmonary dysplasia than did the traditional definition of supplemental oxygen use at 36 weeks (68%, compared with 42%). More than one-half of infants with extremely low GAs had undetermined retinopathy status at the time of discharge. Center differences in management and outcomes were identified.
CONCLUSION: Although the majority of infants with GAs of >or=24 weeks survive, high rates of morbidity among survivors continue to be observed.
Authors:
Barbara J Stoll; Nellie I Hansen; Edward F Bell; Seetha Shankaran; Abbot R Laptook; Michele C Walsh; Ellen C Hale; Nancy S Newman; Kurt Schibler; Waldemar A Carlo; Kathleen A Kennedy; Brenda B Poindexter; Neil N Finer; Richard A Ehrenkranz; Shahnaz Duara; Pablo J Sánchez; T Michael O'Shea; Ronald N Goldberg; Krisa P Van Meurs; Roger G Faix; Dale L Phelps; Ivan D Frantz; Kristi L Watterberg; Shampa Saha; Abhik Das; Rosemary D Higgins;
Related Documents :
21701205 - Growth factors, stem cells and bronchopulmonary dysplasia.
7352515 - Perinatal management and outcome in the infant weighing 1,000 to 2,000 grams.
2359565 - Acute maternal morbidity following classical cesarean delivery of the preterm infant.
22267765 - Proteins involved in extracellular matrix dynamics are associated with respiratory sync...
17189085 - Clinical evaluation of a new starter formula for infants containing live bifidobacteriu...
9334555 - Religiosity and depression: ten-year follow-up of depressed mothers and offspring.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-08-23
Journal Detail:
Title:  Pediatrics     Volume:  126     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-10-04     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  443-56     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Female
Gestational Age
Humans
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases / mortality*,  therapy
Male
National Institute of Child Health and Human Development (U.S.)
Survival Rate
United States
Grant Support
ID/Acronym/Agency:
U10 HD021364/HD/NICHD NIH HHS; U10 HD027851-13/HD/NICHD NIH HHS; U10 HD027851-14/HD/NICHD NIH HHS; U10 HD027851-15/HD/NICHD NIH HHS; U10 HD027851-16/HD/NICHD NIH HHS; U10 HD027851-17/HD/NICHD NIH HHS; U10 HD053089/HD/NICHD NIH HHS; UL1 RR025008/RR/NCRR NIH HHS; UL1 TR000041/TR/NCATS NIH HHS
Investigator
Investigator/Affiliation:
Alan H Jobe / ; Michael S Caplan / ; Avroy A Fanaroff / ; Edward F Donovan / ; Kate Bridges / ; Barbara Alexander / ; Cathy Grisby / ; Marcia Worley Mersmann / ; Holly L Mincey / ; Jody Hessling / ; C Michael Cotten / ; Kathy J Auten / ; Melody B Lohmeyer / ; David P Carlton / ; Ann M Blackwelder / ; Michelle Tidwell / ; Stephanie Wilson Archer / ; James A Lemons / ; Diana D Appel / ; Dianne E Herron / ; Lucy C Miller / ; Leslie Richard / ; Leslie D Wilson / ; Faithe Hamer / ; W Kenneth Poole / ; Betty K Hastings / ; Elizabeth M McClure / ; Jeanette O'Donnell Auman / ; Carolyn Petrie Huitema / ; Kristin M Zaterka-Baxter / ; David K Stevenson / ; Marian M Adams / ; M Bethany Ball / ; Melinda S Proud / ; Andrew W Palmquist / ; Brenda L MacKinnon / ; Ellen Nylen / ; Monica V Collins / ; Shirley S Cosby / ; Maynard R Rasmussen / ; Paul R Wozniak / ; Kathy Arnell / ; Clarence Demetrio / ; Chris Henderson / ; Wade Rich / ; John A Widness / ; Karen J Johnson / ; Ruth Everett-Thomas / ; Conra Backstrom Lacy / ; Linda J Reubens / ; Erica Burnell / ; Sheldon B Korones / ; Abbot R Laptook / ; Charles R Rosenfeld / ; Walid A Salhab / ; Gaynelle Hensley / ; Melissa H Leps / ; Nancy A Miller / ; Jon E Tyson / ; Esther G Akpa / ; Patty A Cluff / ; Anna E Lis / ; Georgia E McDavid / ; Claudia I Franco / ; Beverly Foley Harris / ; Sarah Martin / ; Maegan C Simmons / ; Patti Pierce Tate / ; Bradley A Yoder / ; Karen A Osborne / ; Jennifer J Jensen / ; Cynthia Spencer / ; Kimberlee Weaver-Lewis / ; Robert G Dillard / ; Nancy J Peters / ; Rebecca Bara / ; Geraldine Muran / ; William Oh / ; Angelita M Hensman / ; Patricia Gettner / ; Monica Konstantino / ; JoAnn Poulsen / ; Janet Taft /
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  High Incidence of Invasive Group B Streptococcal Infections in HIV-Exposed Uninfected Infants.
Next Document:  Pentavalent Rotavirus Vaccine and Prevention of Gastroenteritis Hospitalizations in Australia.