Document Detail

Neonatal outcomes and birth weight in pregnancies complicated by maternal thyroid disease.
MedLine Citation:
PMID:  23666815     Owner:  NLM     Status:  MEDLINE    
Maternal hypothyroidism has previously been shown to increase risk for neonatal intensive care treatment, but otherwise the association between thyroid diseases and neonatal morbidity is understudied. The Consortium on Safe Labor, a retrospective cohort (2002-2008), included 223,512 singleton deliveries of which 0.2% had hyperthyroidism, 1.4% primary and 0.1% iatrogenic hypothyroidism, and 1.3% other/unspecified thyroid disease. Logistic regression with generalized estimating equations estimated adjusted odds ratios of adverse outcomes. Intensive care treatment was more common for neonates of women with thyroid disease. Hyperthyroidism and primary hypothyroidism were associated with sepsis, respiratory distress syndrome, transient tachypnea, and apnea. Iatrogenic hypothyroidism was associated with sepsis and neonatal anemia. Hyperthyroidism was also associated with rare outcomes (prevalence, <1%) including cardiomyopathy, retinopathy of prematurity, and neonatal thyroid diseases. Hyperthyroid non-Hispanic black women had higher odds of term infants that weighed <2,500 g, and hypothyroid non-Hispanic white women had higher odds of large-for-gestational-age infants. These analyses were stratified by race/ethnicity due to interaction. Associations were similar in analyses restricted to term infants. In conclusion, thyroid diseases were associated with increased neonatal morbidity. Although we lacked data on treatment during pregnancy, these nationwide data suggest a need for better thyroid disease management to reduce neonatal morbidity.
Tuija Männistö; Pauline Mendola; Uma Reddy; S Katherine Laughon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2013-05-10
Journal Detail:
Title:  American journal of epidemiology     Volume:  178     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-29     Completed Date:  2013-11-04     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  731-40     Citation Subset:  IM    
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MeSH Terms
Birth Weight*
Gestational Age
Intensive Care Units, Neonatal / statistics & numerical data*
Odds Ratio
Perinatal Mortality
Pregnancy Complications / epidemiology*
Pregnancy Outcome / epidemiology*
Sex Distribution
Socioeconomic Factors
Thyroid Diseases / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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