Document Detail

Neonatal onset diffuse cutaneous mastocytosis: a case report and review of the literature.
MedLine Citation:
PMID:  20678092     Owner:  NLM     Status:  In-Data-Review    
Diffuse cutaneous mastocytosis is a rare variant of mast cell disease with widespread erythroderma, which is normally clinically apparent in early infancy. We report the case of a neonate who presented with diffuse erythrodermic rash and bullous lesions. Biopsy specimens showed a dense dermal infiltrate of mast cells. Serum histamine and tryptase levels were elevated. No somatic mutation of the c-kit gene was found. Blistering ceased at 5 months of age, but atopic dermatitis appeared at 6 months and allergic workup revealed a high level of food-specific IgE. Herein, we describe the case and provide the first review of the literature on neonatal onset diffuse cutaneous mastocytosis to clarify the prognosis of this condition.
Hiroshi Koga; Takayuki Kokubo; Mutsumi Akaishi; Koichi Iida; Seigo Korematsu
Publication Detail:
Type:  Journal Article     Date:  2010-07-29
Journal Detail:
Title:  Pediatric dermatology     Volume:  28     ISSN:  1525-1470     ISO Abbreviation:  Pediatr Dermatol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  542-6     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley Periodicals, Inc.
Department of Neonatology, Center for Perinatal Medicine, Oita Prefectural Hospital, Oita, Japan Department of Pediatrics, Faculty of Medicine, Oita University, Oita, Japan.
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