| Neonatal onset diffuse cutaneous mastocytosis: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 20678092 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Diffuse cutaneous mastocytosis is a rare variant of mast cell disease with widespread erythroderma, which is normally clinically apparent in early infancy. We report the case of a neonate who presented with diffuse erythrodermic rash and bullous lesions. Biopsy specimens showed a dense dermal infiltrate of mast cells. Serum histamine and tryptase levels were elevated. No somatic mutation of the c-kit gene was found. Blistering ceased at 5 months of age, but atopic dermatitis appeared at 6 months and allergic workup revealed a high level of food-specific IgE. Herein, we describe the case and provide the first review of the literature on neonatal onset diffuse cutaneous mastocytosis to clarify the prognosis of this condition. |
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Authors:
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Hiroshi Koga; Takayuki Kokubo; Mutsumi Akaishi; Koichi Iida; Seigo Korematsu |
Publication Detail:
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Type: Journal Article Date: 2010-07-29 |
Journal Detail:
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Title: Pediatric dermatology Volume: 28 ISSN: 1525-1470 ISO Abbreviation: Pediatr Dermatol Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406799 Medline TA: Pediatr Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 542-6 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley Periodicals, Inc. |
Affiliation:
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Department of Neonatology, Center for Perinatal Medicine, Oita Prefectural Hospital, Oita, Japan Department of Pediatrics, Faculty of Medicine, Oita University, Oita, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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