Document Detail

Neonatal Mortality and Morbidity in Preterm Infants Born from Assisted Reproductive Technologies.
MedLine Citation:
PMID:  22519364     Owner:  NLM     Status:  Publisher    
Aim:  Premature birth is frequent in infants conceived with assisted reproductive technologies (ART). We sought to determine whether neonatal outcome in ART preterm infants differs from that of spontaneously conceived (SC) preterm infants. Methods:  Data were prospectively collected in infants born ≤32 weeks after ART or SC. We calculated a composite index of severe morbidity (based on occurrences of severe necrotizing enterocolitis, severe intraventricular hemorrhage, periventricular leukomalacia or bronchopulmonary dysplasia). Survival rate without severe morbidity was compared between the two groups. Results:  Six hundred and twelve preterm infants were hospitalized in our tertiary care center: 81 in ART group and 521 in SC group. In the ART group, twin pregnancy (69.1% vs. 15.9%, p<0.001) and inborn delivery (98.8% vs. 90.0%, p<0.01) were more frequent. Gestational age (29 vs.28 weeks, p<0.05) and birth weight (1100 vs. 1020 g, p<0.001) were also higher. Survival without severe morbidity was significantly higher in ART infants (76.5% vs. 55.2%, p<0.001), with the difference mainly observed in infants born ≤28 weeks (22.9% vs. 55.7%, p<0.001). Conclusion:  ART was not associated with adverse neonatal outcome. Differences in pregnancy and neonatal characteristics probably explain the increased survival without severe morbidity in ART infants. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Jc Picaud; S Chalies; C Combes; G Mercier; H Dechaud; G Cambonie
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-20
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s)/Acta P&aelig;diatrica © 2012 Foundation Acta P&aelig;diatrica.
Service de Neonatologie, Hôpital de la Croix Rousse, Hospices Civils de Lyon, F-69004 Lyon, France Université Claude Bernard Lyon1, Faculté de Medecine Lyon Sud Charles Merieux, F-69600 Oullins, France Service de Neonatologie, Hôpital Arnaud de Villeneuve, CHU de Montpellier, F-34000 Montpellier, France Departement d'Information Medicale, Hôpital Arnaud de Villeneuve, CHU de Montpellier, F-34000 Montpellier, France Service d'Obstetrique, Medecine de la Reproduction, Hôpital Arnaud de Villeneuve, CHU de Montpellier, F-34000 Montpellier, France Université Montpellier 1, Faculté de Medecine de Montpellier, F-34000 Montpellier, France.
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