Document Detail


Neonatal Magnesium Levels Correlate with Motor Outcomes in Premature Infants: A Long-Term Retrospective Cohort Study.
MedLine Citation:
PMID:  25414842     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: Chronic neurological deficits are a significant complication of preterm birth. Magnesium supplementation has been suggested to have neuroprotective function in the developing brain. Our objective was to determine whether higher neonatal serum magnesium levels were associated with better long-term neurodevelopmental outcomes in very-low birth weight infants. Study Design: A retrospective cohort of 75 preterm infants (<1500 g, gestational age <27 weeks) had follow-up for the outcomes of abnormal motor exam and for epilepsy. Average total serum magnesium level in the neonate during the period of prematurity was the main independent variable assessed, tested using a Wilcoxon rank-sum test. Results: Higher average serum magnesium level was associated with a statistically significant decreased risk for abnormal motor exam (p = 0.037). A lower risk for epilepsy in the group with higher magnesium level did not reach statistical significance (p = 0.06). Conclusion: This study demonstrates a correlation between higher neonatal magnesium levels and decreased risk for long-term abnormal motor exam. Larger studies are needed to evaluate the hypothesis that higher neonatal magnesium levels can improve long-term neurodevelopmental outcomes.
Authors:
Elizabeth Doll; Jacob Wilkes; Lawrence J Cook; E Kent Korgenski; Roger G Faix; Bradley A Yoder; Rajendu Srivastava; Catherine M T Sherwin; Michael G Spigarelli; Erin A S Clark; Joshua L Bonkowsky
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-05
Journal Detail:
Title:  Frontiers in pediatrics     Volume:  2     ISSN:  2296-2360     ISO Abbreviation:  Front Pediatr     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-21     Completed Date:  -     Revised Date:  2014-11-21    
Medline Journal Info:
Nlm Unique ID:  101615492     Medline TA:  Front Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  120     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Animal Models to Investigate the Pathogenesis of Rheumatic Heart Disease.
Next Document:  Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predict...