| Neonatal lupus erythematosus: three case reports and review of the Chinese literature. | |
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MedLine Citation:
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PMID: 20118099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To recognize the clinical characteristics and outcomes of neonatal lupus erythematosus (NLE), the authors retrospectively review 3 NLE babies in their department and compared their data with 51 NLE cases reported in the available Chinese literature between January 1991 and December 2008. Most of the cases were located near the eastern coast of China, and clinical manifestation of 72.22% of the cases occurred in 2-week-old babies. Skin findings occurred in 94.44% of the patients, 12.96% with complete heart block (CHB), 22.22% with thrombocytopenia, and 14.81% with transient elevated transaminase levels. Cutaneous lesions, thrombocytopenia, and transaminase level showed improvement; 3 CHB cases had persisted after 7 to 10 years follow-up, and 1 case died in 5 months. Twenty-four (44.44%) pregnant woman with anti-Ro/SSA and/or anti-La/SSB antibodies are asymptomatic, and antibody status is first indicated when their child shows symptoms of NLE. Thus, all pregnant women should be screened for anti-Ro/ SSA and anti-La/SSB antibodies. |
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Authors:
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Wei Sun; Tian-Ming Yuan; Li-Hua Chen; Hui-Min Yu |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2010-01-28 |
Journal Detail:
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Title: Clinical pediatrics Volume: 49 ISSN: 1938-2707 ISO Abbreviation: Clin Pediatr (Phila) Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2010-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372606 Medline TA: Clin Pediatr (Phila) Country: United States |
Other Details:
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Languages: eng Pagination: 627-34 Citation Subset: AIM; IM |
Affiliation:
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Zhejiang University School of Medicine, Hangzhou, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antinuclear
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analysis,
immunology China Female Heart Block / congenital*, physiopathology Heart Defects, Congenital / physiopathology Humans Infant, Newborn Lupus Erythematosus, Cutaneous / congenital, immunology, physiopathology Lupus Erythematosus, Systemic / congenital*, immunology, physiopathology Male Maternal-Fetal Exchange Neonatal Screening* Pregnancy Pregnancy Complications / diagnosis* Prognosis Rare Diseases Risk Assessment |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/SS-A antibodies; 0/SS-B antibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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