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Neonatal Hyperthyrotropinemia is Associated With Low Birth Weight: a Twin Study.
MedLine Citation:
PMID:  23184911     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACTOBJECTIVE: Contradictory reports ascribe neonatal hyperthyrotropinemia to prematurity or small weight for gestational age. We aimed to evaluate the association between neonatal hyperthyrotropinemia and birth-weight, recovery rate of the disorder and possible association with perinatal stress. DESIGN: Based on neonatal screening database, a retrospective twin-study was designed where within-pair differences in thyroid function were evaluated while controlling for differences in gestational age and thyroid affecting environmental confounders. METHODS: 2595 twin pairs that were screened both for TSH and T4 over three years were included. TSH and T4 levels were evaluated along with birth-weight, birth order, gender and 17-hydroxyprogesterone that was considered as a surrogate marker for stress. RESULTS: 7.2% of the twin pairs had neonatal hyperthyrotropinemia. Among 156 pairs, hyperthyrotropinemia was more prevalent in the smaller twins (64%; p<0.001), especially in the discordant pairs (76%; p=0.001). 75% of the twins demonstrated a recovery within the first few weeks of life. 17-hydroxyprogesterone levels were similarly distributed between twins with and without hyperthyrotropinemia. In a cohort of 1534 twin pairs with normal thyroid function, mean TSH levels were significantly higher in the smaller- than in the larger-twin in the whole group (4.1±3.2 vs. 3.8±2.9 mIU/L; p<0.001) and especially among discordant twins (4.7±3.4 vs. 3.8±3.0 mIU/L; p<0.001). CONCLUSIONS: Elevated TSH levels are associated with low birth-weight, both in infants with hyperthyrotropinemia and in normal neonates. A rapid recovery rate is expected in most cases.
Authors:
Amnon Zung; Arie Yehieli; Shlomo Almashanu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-26
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  -     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
A Zung, Pediatric Endocrinology Unit, Kaplan Medical Center, affiliated with the Hebrew University of Jerusalem, Rehovot, 76100, Israel.
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