Document Detail

Neonatal enteroviral sepsis/meningoencephalitis and hemophagocytic lymphohistiocytosis: diagnostic challenges.
MedLine Citation:
PMID:  21089006     Owner:  NLM     Status:  In-Data-Review    
We present the clinical course of three neonates with proven enteroviral infection and an initial clinical picture suggestive of hemophagocytic lymphohistiocytosis (HLH). After a complete workup, only one was treated for HLH. Of particular interest, the first newborn presented with hemophagocytic cells in the cerebrospinal fluid (CSF) and proved to have enteroviral meningoencephalitis but was ultimately not diagnosed with HLH. A fourth infant, who fulfilled the diagnostic criteria for HLH but did not have enteroviral infection, is included for comparison. We suggest that severe neonatal enteroviral infection and HLH are difficult to distinguish. Careful assessment is recommended, as prognosis and treatment differ between these two entities. Literature regarding neonatal enteroviral infection and HLH is reviewed, to demonstrate the continuum between the inflammation triggered by enteroviral infection and the occurrence of HLH, as well as their comparable CSF findings.
Kristen Earley Lindamood; Patricia Fleck; Anupama Narla; Jo-Anne Vergilio; Barbara A Degar; Michael Baldwin; Pia Wintermark
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Publication Detail:
Type:  Journal Article     Date:  2010-11-18
Journal Detail:
Title:  American journal of perinatology     Volume:  28     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-46     Citation Subset:  IM    
Copyright Information:
© Thieme Medical Publishers.
Division of Newborn Medicine, Children's Hospital Boston, Boston, Massachusetts.
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