| Neonatal Diabetes: An Expanding List of Genes Allows for Improved Diagnosis and Treatment. | |
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MedLine Citation:
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PMID: 21993633 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There has been major progress in recent years uncovering the genetic causes of diabetes presenting in the first year of life. Twenty genes have been identified to date. The most common causes accounting for the majority of cases are mutations in the genes encoding the two subunits of the ATP-sensitive potassium channel (K(ATP)), KCNJ11 and ABCC8, and the insulin gene (INS), as well as abnormalities in chromosome 6q24. Patients with activating mutations in KCNJ11 and ABCC8 can be treated with oral sulfonylureas in lieu of insulin injections. This compelling example of personalized genetic medicine leading to improved glucose regulation and quality of life may-with continued research-be repeated for other forms of neonatal diabetes in the future. |
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Authors:
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Siri Atma W Greeley; Rochelle N Naylor; Louis H Philipson; Graeme I Bell |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-13 |
Journal Detail:
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Title: Current diabetes reports Volume: - ISSN: 1539-0829 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093791 Medline TA: Curr Diab Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Kovler Diabetes Center, The University of Chicago, MC 1027/N235, 5841 South Maryland Avenue, Chicago, IL, 60637, USA, sgreeley@peds.bsd.uchicago.edu. |
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