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Neonatal Candidiasis: Results of a 8-Year Study.
MedLine Citation:
PMID:  22320707     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  The aim of this study is to evaluate the risk factors, demographic features, treatment and clinical outcome associated with candidemia in neonatal intensive care unit (NICU) within a 8-year period. Methods:  The data of infants who were diagnosed as candidemia, were evaluated. Results:  Between January 2000 and December 2007, a total of 28 candidemia episodes were identified in 28 infants. We documented 1.1% candidemia incidence in the NICU. The species most frequently causing candidemia were Candida parapsilosis (57.1%), followed by Candida albicans (42.9%). The main predisposing factors for candidemia with C.parapsilosis included presence of maternal preeclampsia, prematurity, prolonged mechanical ventilation, prolonged total parenteral nutrition day and presence of jaundice. Retinopathy of prematurity and bronchopulmonary dysplasia were the most frequently seen underlying illness in infants with C.parapsilosis. In this study, 13 infants (46.4%) had evidence of organ dissemination. Mortality rate was found as 42.8% in infants with candidemia. Mean leukocyte counts and mean CRP were significantly higher in neonates who died compared with those who survived. Conclusions:  C. parapsilosis (57.1%) was the leading causative organism, followed by C.albicans (42.9%) in infants. Rate of organ dissemination in our cases was high. Mortality rate was found to be 42.8% in infants with candidemia. © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Authors:
Solmaz Celebi; Mustafa Hacimustafaoglu; Nilgun Koksal; Hilal Ozkan; Merih Cetinkaya; Beyza Ener
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-9
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Affiliation:
Uludag University Medical Faculty, Department of Pediatrics, Division of Pediatric Infectious Diseases, Gorukle, Bursa, Turkey Uludag University Medical Faculty, Department of Pediatrics, Division of Neonatology, Gorukle, Bursa, Turkey Uludag University Medical Faculty, Department of Microbiology, Gorukle, Bursa, Turkey.
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