Document Detail


Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures.
MedLine Citation:
PMID:  17080094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to examine the frequency of normal cerebrospinal fluid (CSF) parameters in Candida meningitis and the proportion of candidemia associated with Candida meningitis. STUDY DESIGN: We evaluated the initial lumbar puncture results from infants discharged from 150 Neonatal Intensive Care Units between 1997 and 2004. Candida meningitis was diagnosed by a positive CSF culture or positive Gram stain for yeast. We calculated two-tailed P-values using non-parametric testing, Mann-Whitney, Kruskal-Wallis or Fisher's exact tests where appropriate. RESULTS: Twenty infants had culture-positive Candida meningitis. Normal CSF parameters were found in 43% (3/7) of the infants with Candida meningitis and only 37% (7/19) of them had positive blood cultures for Candida. CONCLUSION: Normal CSF parameters do not exclude the diagnosis of neonatal Candida meningitis. The majority of infants in this cohort with Candida meningitis did not have evidence of candidemia at the time of diagnosis.
Authors:
M Cohen-Wolkowiez; P B Smith; B Mangum; W J Steinbach; B D Alexander; C M Cotten; R H Clark; T J Walsh; D K Benjamin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-11-02
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  27     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-30     Completed Date:  2007-03-30     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-100     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Duke University, Durham, NC 27705, USA.
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / analysis
Candidiasis / blood*,  cerebrospinal fluid*
Female
Humans
Infant, Newborn
Leukocyte Count
Male
Meningitis, Bacterial / blood*,  cerebrospinal fluid*,  microbiology
Sepsis / cerebrospinal fluid,  microbiology*
Grant Support
ID/Acronym/Agency:
HD044799-01/HD/NICHD NIH HHS; T32 AI052080/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose

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