Document Detail

Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants.
MedLine Citation:
PMID:  2210089     Owner:  NLM     Status:  MEDLINE    
An infant with dysmorphic features was born to an epileptic mother who had taken phenytoin and sodium valproate throughout pregnancy. The infant began to have intractable seizures 10 minutes after delivery, and retrospective reports from the mother suggested they may have occurred in utero. Ultrasound examination of the brain showed a very wide subarachnoid space and CT confirmed cerebral and cerebellar underdevelopment. The infant died at three days of age and autopsy revealed a small brain with neocerebellar hypoplasia. This case might represent an extreme example of anticonvulsant teratogenicity.
W Squier; P L Hope; R H Lindenbaum
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  32     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-11-06     Completed Date:  1990-11-06     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  737-42     Citation Subset:  IM    
Department of Neuropathology, Radcliffe Infirmary, Oxford.
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MeSH Terms
Abnormalities, Drug-Induced / pathology*
Cerebellum / drug effects*,  pathology
Drug Therapy, Combination
Epilepsy / drug therapy*
Nerve Degeneration / drug effects
Neurons / drug effects
Phenytoin / administration & dosage,  adverse effects*
Pregnancy Complications / drug therapy*
Valproic Acid / administration & dosage,  adverse effects*
Reg. No./Substance:
57-41-0/Phenytoin; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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