| Neoadjuvant chemotherapy followed by radical hysterectomy for invasive cervical cancer diagnosed during pregnancy: report of a case and review of the literature. | |
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MedLine Citation:
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PMID: 16681782 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although cervical carcinoma is among the most frequently encountered malignancies during pregnancy, only four cases of neoadjuvant chemotherapy during pregnancy have been reported. A 28-year-old A0P1G2M0 was diagnosed at 15 weeks with stage Ib1 invasive squamous cervical cancer. Because she strongly desired the continuation of this pregnancy, after extensive counseling she was treated with 75 mg/m(2) cisplatin every 10 days starting at 17 weeks. After six cycles, clinically and radiologically stable disease with normalization of the squamous cell carcinoma tumor marker was obtained. An elective cesarean delivery followed by radical hysterectomy and lymphadenectomy was performed at 32 weeks gestation. The pathology report revealed a moderately differentiated squamous cell carcinoma of 3.5 cm, and all 33 lymph nodes were free of disease. Neonatal examination of the baby could not reveal any abnormalities, and this was confirmed at 6 months. The use of neoadjuvant chemotherapy enabled us to continue this pregnancy until the fetus was viable. Cisplatin did not influence the short-term outcome, but only a long-term follow-up will inform us on its safety during pregnancy. |
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Authors:
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S Caluwaerts; K VAN Calsteren; L Mertens; L Lagae; P Moerman; M Hanssens; K Wuyts; I Vergote; F Amant |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 16 ISSN: 1048-891X ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2006 Mar-Apr |
Date Detail:
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Created Date: 2006-05-09 Completed Date: 2006-10-12 Revised Date: 2006-11-07 |
Medline Journal Info:
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Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 905-8 Citation Subset: IM |
Affiliation:
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Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents / therapeutic use* Carcinoma, Squamous Cell / drug therapy, surgery, therapy* Cervical Intraepithelial Neoplasia / drug therapy, surgery, therapy* Chemotherapy, Adjuvant Cisplatin / therapeutic use* Combined Modality Therapy Female Humans Hysterectomy* Infant Live Birth Male Neoadjuvant Therapy* Neoplasm Invasiveness / diagnosis* Pregnancy Pregnancy Complications, Neoplastic* Pregnancy Outcome Treatment Outcome Uterine Cervical Neoplasms / drug therapy, surgery, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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