Document Detail

Neoadjuvant chemotherapy for advanced gastric cancer: a meta-analysis.
MedLine Citation:
PMID:  21105197     Owner:  NLM     Status:  MEDLINE    
AIM: To study the value of neoadjuvant chemotherapy (NAC) for advanced gastric cancer by performing a meta-analysis of the published studies.
METHODS: All published controlled trials of NAC for advanced gastric cancer vs no therapy before surgery were searched. Studies that included patients with metastases at enrollment were excluded. Databases included Cochrane Library of Clinical Comparative Trials, MEDLINE, Embase, and American Society of Clinical Oncology meeting abstracts from 1978 to 2010. The censor date was up to April 2010. Primary outcome was the odds ratio (OR) for improving overall survival rate of patients with advanced gastric cancer. Secondary outcome was the OR for down-staging tumor and increasing R0 resection in patients with advanced gastric cancer. Safety analyses were also performed. All calculations and statistical tests were performed using RevMan 5.0 software.
RESULTS: A total of 2271 patients with advanced gastric cancer enrolled in 14 trials were divided into NAC group (n = 1054) and control group (n = 1217). The patients were followed up for a median time of 54 mo. NAC significantly improved the survival rate [OR = 1.27, 95% confidence interval (CI): 1.04-1.55], tumor stage (OR = 1.71, 95% CI: 1.26-2.33) and R0 resection rate (OR = 1.51, 95% CI: 1.19-1.91) of patients with advanced gastric cancer. No obvious safety concerns were raised in these trials.
CONCLUSION: NAC can improve tumor stage and survival rate of patients with advanced gastric cancer with a rather good safety.
Wei Li; Jing Qin; Yi-Hong Sun; Tian-Shu Liu
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-04     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5621-8     Citation Subset:  IM    
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MeSH Terms
Chemotherapy, Adjuvant
Chi-Square Distribution
Disease-Free Survival
Neoadjuvant Therapy
Neoplasm Staging
Odds Ratio
Risk Assessment
Risk Factors
Stomach Neoplasms / drug therapy*,  mortality,  pathology,  surgery
Survival Rate
Time Factors
Treatment Outcome
Comment In:
World J Gastroenterol. 2011 Oct 28;17(40):4542-4   [PMID:  22110287 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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