Document Detail

Neoadjuvant chemotherapy followed by cesarean radical hysterectomy in a triplet pregnancy complicated by clear cell carcinoma of the cervix: a case presentation and literature review.
MedLine Citation:
PMID:  22801030     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a triplet pregnancy complicated by clear cell cervical carcinoma that was managed using neoadjuvant chemotherapy followed by caesarean radical hysterectomy.
PATIENT HISTORY: A 26-year-old woman had a diagnosis of cervical clear cell carcinoma, which was International Federation of Gynecology and Obstetrics stage IB1, at 18 weeks of gestation during a triplet pregnancy. Owing to the patient's strong desire for full-term pregnancy, 3 cycles of neoadjuvant chemotherapy was administered after magnetic resonance imaging evaluation of the tumor. The patient underwent cesarean delivery and radical hysterectomy at gestational week 32. The hysterectomy specimen revealed stage IB1 clear cell adenocarcinoma of the cervix. The neonates and the mother did not have any complications related to the treatment during 36 months of follow-up.
CONCLUSION: To the best of our knowledge, this is the first report of a triplet pregnancy complicated by cervical clear cell carcinoma that was successfully treated with neoadjuvant chemotherapy and cesarean radical hysterectomy. Our experience and literature review suggest that neoadjuvant chemotherapy for cervical carcinoma diagnosed during pregnancy is associated with excellent oncologic and fetal outcome; therefore, it may be considered as a temporary fertility-sparing approach in selected patients with a strong desire for full-term pregnancy. Nonetheless, additional research and long-term follow-up are needed to reach a more definitive conclusion.
Ali Ayhan; Polat Dursun; Burcu Kisa Karakaya; Ozlem Ozen; Cagla Tarhan
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society     Volume:  22     ISSN:  1525-1438     ISO Abbreviation:  Int. J. Gynecol. Cancer     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-23     Completed Date:  2013-02-05     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  9111626     Medline TA:  Int J Gynecol Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1198-202     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma, Clear Cell / complications,  pathology,  therapy*
Antineoplastic Agents / therapeutic use*
Cesarean Section
Chemotherapy, Adjuvant
Cisplatin / therapeutic use
Combined Modality Therapy
Infant, Newborn
Neoadjuvant Therapy*
Pregnancy Complications, Neoplastic / etiology,  pathology,  therapy*
Pregnancy, Triplet
Review Literature as Topic
Uterine Cervical Neoplasms / complications,  pathology,  therapy*
Reg. No./Substance:
0/Antineoplastic Agents; Q20Q21Q62J/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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