Document Detail


Nematode-bacterium symbioses--cooperation and conflict revealed in the "omics" age.
MedLine Citation:
PMID:  22983035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nematodes are ubiquitous organisms that have a significant global impact on ecosystems, economies, agriculture, and human health. The applied importance of nematodes and the experimental tractability of many species have promoted their use as models in various research areas, including developmental biology, evolutionary biology, ecology, and animal-bacterium interactions. Nematodes are particularly well suited for the investigation of host associations with bacteria because all nematodes have interacted with bacteria during their evolutionary history and engage in a variety of association types. Interactions between nematodes and bacteria can be positive (mutualistic) or negative (pathogenic/parasitic) and may be transient or stably maintained (symbiotic). Furthermore, since many mechanistic aspects of nematode-bacterium interactions are conserved, their study can provide broader insights into other types of associations, including those relevant to human diseases. Recently, genome-scale studies have been applied to diverse nematode-bacterial interactions and have helped reveal mechanisms of communication and exchange between the associated partners. In addition to providing specific information about the system under investigation, these studies also have helped inform our understanding of genome evolution, mutualism, and innate immunity. In this review we discuss the importance and diversity of nematodes, "omics"' studies in nematode-bacterial systems, and the wider implications of the findings.
Authors:
Kristen E Murfin; Adler R Dillman; Jeremy M Foster; Silvia Bulgheresi; Barton E Slatko; Paul W Sternberg; Heidi Goodrich-Blair
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  The Biological bulletin     Volume:  223     ISSN:  1939-8697     ISO Abbreviation:  Biol. Bull.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-09-17     Completed Date:  2013-01-25     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  2984727R     Medline TA:  Biol Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-102     Citation Subset:  IM    
Affiliation:
Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / chemistry,  genetics,  growth & development*
Bacterial Physiological Phenomena*
Genomics / methods
Metabolomics / methods
Nematoda / microbiology*,  physiology*
Proteomics / methods
Symbiosis*
Transcriptome
Grant Support
ID/Acronym/Agency:
T32 AI055397/AI/NIAID NIH HHS; T32 GM007616/GM/NIGMS NIH HHS; T32GM07616/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute
Comments/Corrections

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