| Nematode-bacterium symbioses--cooperation and conflict revealed in the "omics" age. | |
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MedLine Citation:
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PMID: 22983035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nematodes are ubiquitous organisms that have a significant global impact on ecosystems, economies, agriculture, and human health. The applied importance of nematodes and the experimental tractability of many species have promoted their use as models in various research areas, including developmental biology, evolutionary biology, ecology, and animal-bacterium interactions. Nematodes are particularly well suited for the investigation of host associations with bacteria because all nematodes have interacted with bacteria during their evolutionary history and engage in a variety of association types. Interactions between nematodes and bacteria can be positive (mutualistic) or negative (pathogenic/parasitic) and may be transient or stably maintained (symbiotic). Furthermore, since many mechanistic aspects of nematode-bacterium interactions are conserved, their study can provide broader insights into other types of associations, including those relevant to human diseases. Recently, genome-scale studies have been applied to diverse nematode-bacterial interactions and have helped reveal mechanisms of communication and exchange between the associated partners. In addition to providing specific information about the system under investigation, these studies also have helped inform our understanding of genome evolution, mutualism, and innate immunity. In this review we discuss the importance and diversity of nematodes, "omics"' studies in nematode-bacterial systems, and the wider implications of the findings. |
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Authors:
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Kristen E Murfin; Adler R Dillman; Jeremy M Foster; Silvia Bulgheresi; Barton E Slatko; Paul W Sternberg; Heidi Goodrich-Blair |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: The Biological bulletin Volume: 223 ISSN: 1939-8697 ISO Abbreviation: Biol. Bull. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-09-17 Completed Date: 2013-01-25 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 2984727R Medline TA: Biol Bull Country: United States |
Other Details:
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Languages: eng Pagination: 85-102 Citation Subset: IM |
Affiliation:
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Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria / chemistry, genetics, growth & development* Bacterial Physiological Phenomena* Genomics / methods Metabolomics / methods Nematoda / microbiology*, physiology* Proteomics / methods Symbiosis* Transcriptome |
| Grant Support | |
ID/Acronym/Agency:
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T32 AI055397/AI/NIAID NIH HHS; T32 GM007616/GM/NIGMS NIH HHS; T32GM07616/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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