Document Detail


Nelfinavir and its active metabolite, hydroxy-t-butylamidenelfinavir (M8), are transferred in small quantities to breast milk and do not reach biologically significant concentrations in breast-feeding infants whose mothers are taking nelfinavir.
MedLine Citation:
PMID:  21876052     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antiretroviral drugs cross from maternal plasma to breast milk and from breast milk to the infant in different concentrations. We measured concentrations of nelfinavir and its active metabolite (M8) in maternal plasma and breast milk from women and in dried blood spots collected from their infants at delivery and postnatal weeks 2, 6, 14, and 24 in the Kisumu Breastfeeding Study, Kisumu, Kenya. Nelfinavir-based antiretroviral regimens given to mothers as prevention of mother-to-child HIV transmission (PMTCT) do not expose the breast-feeding infant to biologically significant concentrations of nelfinavir or M8.
Authors:
Paul J Weidle; Clement Zeh; Amy Martin; Richard Lando; Frank Angira; Joseph Osoga; Paul Ogindo; Sonali Girde; Timothy D Minniear; Timothy K Thomas
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2011-08-29
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  55     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-17     Completed Date:  2012-05-10     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5168-71     Citation Subset:  IM    
Affiliation:
Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. pweidle@cdc.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-HIV Agents / blood*,  metabolism*
Breast Feeding
Female
Humans
Milk, Human / metabolism*
Nelfinavir / analogs & derivatives*,  blood*,  metabolism*
Pregnancy
Young Adult
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/hydroxy-t-butylamidenelfinavir; 159989-64-7/Nelfinavir
Comments/Corrections

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