| Nelfinavir and its active metabolite, hydroxy-t-butylamidenelfinavir (M8), are transferred in small quantities to breast milk and do not reach biologically significant concentrations in breast-feeding infants whose mothers are taking nelfinavir. | |
| | |
MedLine Citation:
|
PMID: 21876052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Antiretroviral drugs cross from maternal plasma to breast milk and from breast milk to the infant in different concentrations. We measured concentrations of nelfinavir and its active metabolite (M8) in maternal plasma and breast milk from women and in dried blood spots collected from their infants at delivery and postnatal weeks 2, 6, 14, and 24 in the Kisumu Breastfeeding Study, Kisumu, Kenya. Nelfinavir-based antiretroviral regimens given to mothers as prevention of mother-to-child HIV transmission (PMTCT) do not expose the breast-feeding infant to biologically significant concentrations of nelfinavir or M8. |
| | |
Authors:
|
Paul J Weidle; Clement Zeh; Amy Martin; Richard Lando; Frank Angira; Joseph Osoga; Paul Ogindo; Sonali Girde; Timothy D Minniear; Timothy K Thomas |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2011-08-29 |
Journal Detail:
|
Title: Antimicrobial agents and chemotherapy Volume: 55 ISSN: 1098-6596 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-10-17 Completed Date: 2012-05-10 Revised Date: 2013-05-23 |
Medline Journal Info:
|
Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
|
Languages: eng Pagination: 5168-71 Citation Subset: IM |
Affiliation:
|
Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. pweidle@cdc.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anti-HIV Agents / blood*, metabolism* Breast Feeding Female Humans Milk, Human / metabolism* Nelfinavir / analogs & derivatives*, blood*, metabolism* Pregnancy Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Anti-HIV Agents; 0/hydroxy-t-butylamidenelfinavir; 159989-64-7/Nelfinavir |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of mutations outside the V3 region on coreceptor tropism phenotypically assessed in patients ...
Next Document: In vitro activity of antiretroviral drugs against Plasmodium falciparum.