Document Detail

Negligible serum anti-müllerian hormone: pregnancy and birth after a 1-month course of an oral contraceptive, ovarian hyperstimulation, and intracytoplasmic sperm injection.
MedLine Citation:
PMID:  19410249     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe a patient with isolated negligible (<0.5 ng/mL or <3.6 pmol/L) anti-müllerian hormone (AMH) levels who underwent intracytoplasmic sperm injection (ICSI) for severe oligoasthenoteratozoospermia, displayed ovarian hyperstimulation after a 1-month course of an oral contraceptive (OC), had a singleton pregnancy and delivered a healthy boy. DESIGN: Case report. SETTING: Reproductive center at a private hospital. PATIENT(S): A 34-year-old woman with isolated negligible (<0.5 ng/mL or <3.6 pmol/L) AMH level and poor response to controlled ovarian hyperstimulation (COH) and her 38-year-old partner with severe oligoasthenoteratozoospermia. INTERVENTION(S): A 1-month course of an OC, modified minimal stimulation cycle with recombinant FSH, antagonist (cetrorelix) administration to inhibit LH surge, triggered ovulation using 10,000 U of hCG and ICSI. MAIN OUTCOME MEASURE(S): Level of AMH, pregnancy, and birth. RESULT(S): Three high quality embryos were obtained and transferred 48 hours after ICSI. Transvaginal ultrasound at 8 weeks' gestation showed a vital singleton pregnancy. The pregnancy continued uncomplicated. The patient gave birth to a healthy boy, weighing 3,280 g, by caesarean section at 39 weeks' gestation. CONCLUSION(S): Ovarian hyperstimulation, pregnancy, and birth may occur after a short course of an OC and ICSI in poor responder, normogonadotropic, regularly menstruating young women with isolated negligible AMH.
Angelo Tocci; Susanna Ferrero; Marcello Iacobelli; Ermanno Greco
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-05-01
Journal Detail:
Title:  Fertility and sterility     Volume:  92     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-07-29     Revised Date:  2010-09-03    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395.e9-395.e12     Citation Subset:  IM    
European Hospital, Reproductive Medicine Unit, Via Portuense 70, Rome, Italy.
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MeSH Terms
Anti-Mullerian Hormone / blood*,  deficiency
Cesarean Section
Enzyme-Linked Immunosorbent Assay
Estradiol / blood
Follicle Stimulating Hormone / blood
Infant, Newborn
Live Birth
Ovulation Induction / methods*
Sperm Injections, Intracytoplasmic*
Reg. No./Substance:
50-28-2/Estradiol; 80497-65-0/Anti-Mullerian Hormone; 9002-68-0/Follicle Stimulating Hormone
Comment In:
Fertil Steril. 2010 Sep;94(4):e70; author reply e71-2   [PMID:  20691437 ]
Fertil Steril. 2009 Aug;92(2):e40; author reply e41   [PMID:  19580967 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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