Document Detail

Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway.
MedLine Citation:
PMID:  14670299     Owner:  NLM     Status:  MEDLINE    
Factors involved in pregnancy failure due to abnormal fetomaternal tolerance are poorly understood. Here we describe distinct defects in placenta formation and subsequent pregnancy loss solely dependent on the activation of the complement alternative pathway and the effector mechanisms provided by the maternal C3. Surprisingly, this effect is independent of other complement activation pathways and of the effector mechanisms provided by other complement components. These findings provide significant insight into the role of the innate immune system in human pregnancy failure, a frequent clinical outcome.
Dailing Mao; Xiaobo Wu; Christine Deppong; Lindzy D Friend; Gregory Dolecki; D Michael Nelson; Hector Molina
Related Documents :
9537059 - The fetus as an allograft: a longitudinal study of normal human pregnancies studied wit...
23374059 - An algorithm for the estimation of gestational age at the time of fetal death.
7066259 - Immune status of anaemic pregnant women.
4020779 - Pregnant and pseudopregnant mice produce a low cytotoxic alloantibody response when cha...
9286859 - Changes in leukocyte, granulocyte and lymphocyte counts following antenatal betamethaso...
2925229 - Site-directed differences in the immune response to the fetus.
10426679 - Fetal ultrasound biometry: 2. abdomen and femur length reference values.
2454439 - Amniotic fluid alpha-fetoprotein and acetylcholinesterase in early genetic amniocentesis.
20120139 - Clinical presentation and complications in patients with unsafe abortions in university...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunity     Volume:  19     ISSN:  1074-7613     ISO Abbreviation:  Immunity     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-12     Completed Date:  2004-01-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  813-22     Citation Subset:  IM    
Rheumatology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abortion, Spontaneous / immunology,  metabolism*
Complement C3 / metabolism*
Complement C5 / metabolism
Complement Pathway, Alternative / physiology*
Placenta / metabolism,  pathology
Grant Support
Reg. No./Substance:
0/Complement C3; 0/Complement C5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thermodynamic analysis of degenerate recognition by the NKG2D immunoreceptor: not induced fit but ri...
Next Document:  CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberc...