| Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway. | |
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MedLine Citation:
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PMID: 14670299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Factors involved in pregnancy failure due to abnormal fetomaternal tolerance are poorly understood. Here we describe distinct defects in placenta formation and subsequent pregnancy loss solely dependent on the activation of the complement alternative pathway and the effector mechanisms provided by the maternal C3. Surprisingly, this effect is independent of other complement activation pathways and of the effector mechanisms provided by other complement components. These findings provide significant insight into the role of the innate immune system in human pregnancy failure, a frequent clinical outcome. |
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Authors:
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Dailing Mao; Xiaobo Wu; Christine Deppong; Lindzy D Friend; Gregory Dolecki; D Michael Nelson; Hector Molina |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Immunity Volume: 19 ISSN: 1074-7613 ISO Abbreviation: Immunity Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-12 Completed Date: 2004-01-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
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Languages: eng Pagination: 813-22 Citation Subset: IM |
Affiliation:
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Rheumatology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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immunology,
metabolism* Animals Complement C3 / metabolism* Complement C5 / metabolism Complement Pathway, Alternative / physiology* Female Mice Placenta / metabolism, pathology Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI40576/AI/NIAID NIH HHS; R01 AI44912/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Complement C5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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