Document Detail


Neglected external validity in reports of randomized trials: the example of hip and knee osteoarthritis.
MedLine Citation:
PMID:  19248133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate data reporting related to external validity from randomized controlled trials (RCTs) assessing pharmacologic and nonpharmacologic treatment for hip and knee osteoarthritis (OA).
METHODS: All RCTs assessing pharmacologic treatments and nonpharmacologic treatments for hip and knee OA indexed between January 2002 and December 2006 were selected. A sample of 120 articles were randomly selected: 30 each assessing pharmacologic treatments, surgery or technical interventions, rehabilitation, and nonimplantable devices.
RESULTS: The country was clearly reported in 25 (21%) reports, the setting described in 40 (33%) reports, and the number of centers in 54 (45%). Details about the centers (volume of care) were given in 24 (20%) reports. Rates were lower for surgical trials for the country (3%), the setting (3%), the number of centers (13%), and details about the centers (7%). The intervention was adequately described in all pharmacologic reports and in >80% of rehabilitation reports. The technical procedure was given in all surgical intervention trial reports, but the type of anesthesia was reported in 4 (13%), preoperative care in 2 (7%), and postoperative care in 15 (50%). The device was described in 93% of device trial reports, but the manufacturer was reported in only 33%.
CONCLUSION: There is low reporting of data related to external validity in reports of RCTs assessing pharmacologic and nonpharmacologic treatments for hip and knee OA.
Authors:
Nizar Ahmad; Isabelle Boutron; David Moher; Isabelle Pitrou; Carine Roy; Philippe Ravaud
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  61     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-09     Completed Date:  2009-05-26     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-9     Citation Subset:  AIM; IM    
Affiliation:
INSERM U738, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Université Paris 7, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Male
Osteoarthritis, Hip / therapy*
Osteoarthritis, Knee / therapy*
Randomized Controlled Trials as Topic / methods*
Reproducibility of Results
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