Document Detail

Neglect-associated fatal Marchiafava-Bignami disease in a non-alcoholic woman.
MedLine Citation:
PMID:  11724438     Owner:  NLM     Status:  MEDLINE    
We present the case of an 80-year-old malnourished and non-alcoholic woman who died from neglect-associated Marchiafava-Bignami disease, an illness usually almost exclusively occurring in male alcoholics. The patient had been bedridden for several months and had been looked after by her son. The patient was admitted to hospital in an extremely poor care condition suffering from severe exsiccosis, pressure sores and marasmus and died shortly afterwards. The initial post-mortem examination could not establish a definite cause of death, however, upon neuropathological examination a necrotising cystic lesion in the left cingulate gyrus as well as a central necrosis in the corpus callosum indicative of Marchiafava-Bignami disease were revealed. This is the first known case of Marchiafava-Bignami disease in a non-alcoholic woman and the first case in the forensic setting of neglect.
C H Rickert; B Karger; K Varchmin-Schultheiss; B Brinkmann; W Paulus
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of legal medicine     Volume:  115     ISSN:  0937-9827     ISO Abbreviation:  Int. J. Legal Med.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-28     Completed Date:  2002-02-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9101456     Medline TA:  Int J Legal Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  90-3     Citation Subset:  IM    
Institute of Neuropathology, University Clinics Münster, Germany.
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MeSH Terms
Aged, 80 and over
Corpus Callosum / pathology
Demyelinating Diseases / pathology*
Elder Abuse*
Fatal Outcome
Forensic Medicine
Nutrition Disorders / complications*,  pathology

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