Document Detail


Negative relationships between erythrocyte Ca-pump activity and lead levels in mothers and newborns.
MedLine Citation:
PMID:  11191638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lead poisoning induces hematological, gastrointestinal and neurological dysfunctions. One of the potential mechanisms is the inhibition of calcium-pump (Ca-pump), a transport protein. We investigated the effects of an environmental low lead exposure on Ca-pump activity in 247 mothers and their newborns. Maternal and cord blood, and newborn and mother hair, were sampled at delivery. Geometric means for mother and cord blood lead (Pb-B), and for mother and newborn hair lead (Pb-H), were 6.3 and 4.8 microg/dl, and 1.7 and 1.1 microg/g. Means for mother and cord basal Ca-pump activities were 2,442 and 2,675 nM/mg/hr. Mother enzymatic activity was negatively related to her Pb-B and Pb-H and to the cord Pb-B and newborn Pb-H levels. Newborn enzymatic activity was negatively related to his Pb-H level only. Adjustment for gestational age, child's sex, mother's age at delivery, alcohol, coffee and tea consumption, and smoking habits during pregnancy did not modify these relationships. Our findings support the hypothesis that lead toxicity could be in part mediated by a reduction of Ca-pump activity. This effect could be observed at low environmental exposure, in mothers and newborns.
Authors:
D Campagna; G Huel; G Hellier; F Girard; J Sahuquillo; A Fagot-Campagna; J Godin; P Blot
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  68     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-12     Completed Date:  2001-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-15     Citation Subset:  IM    
Affiliation:
French National Institute of Medical Research and Health (INSERM-U472), Epidemiology and Biostatistics Research Unit, Villejuif.
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MeSH Terms
Descriptor/Qualifier:
Adult
Calcium-Transporting ATPases / metabolism*
Calmodulin / pharmacology
Environmental Exposure / analysis
Erythrocyte Membrane / drug effects,  enzymology*
Female
France / epidemiology
Hair / chemistry
Humans
Infant, Newborn
Lead / blood*
Lead Poisoning / epidemiology*
Male
Maternal-Fetal Exchange*
Pregnancy
Risk Factors
Chemical
Reg. No./Substance:
0/Calmodulin; 7439-92-1/Lead; EC 3.6.1.8/Calcium-Transporting ATPases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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