| Negative relationships between erythrocyte Ca-pump activity and lead levels in mothers and newborns. | |
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MedLine Citation:
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PMID: 11191638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lead poisoning induces hematological, gastrointestinal and neurological dysfunctions. One of the potential mechanisms is the inhibition of calcium-pump (Ca-pump), a transport protein. We investigated the effects of an environmental low lead exposure on Ca-pump activity in 247 mothers and their newborns. Maternal and cord blood, and newborn and mother hair, were sampled at delivery. Geometric means for mother and cord blood lead (Pb-B), and for mother and newborn hair lead (Pb-H), were 6.3 and 4.8 microg/dl, and 1.7 and 1.1 microg/g. Means for mother and cord basal Ca-pump activities were 2,442 and 2,675 nM/mg/hr. Mother enzymatic activity was negatively related to her Pb-B and Pb-H and to the cord Pb-B and newborn Pb-H levels. Newborn enzymatic activity was negatively related to his Pb-H level only. Adjustment for gestational age, child's sex, mother's age at delivery, alcohol, coffee and tea consumption, and smoking habits during pregnancy did not modify these relationships. Our findings support the hypothesis that lead toxicity could be in part mediated by a reduction of Ca-pump activity. This effect could be observed at low environmental exposure, in mothers and newborns. |
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Authors:
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D Campagna; G Huel; G Hellier; F Girard; J Sahuquillo; A Fagot-Campagna; J Godin; P Blot |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 68 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-12 Completed Date: 2001-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 203-15 Citation Subset: IM |
Affiliation:
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French National Institute of Medical Research and Health (INSERM-U472), Epidemiology and Biostatistics Research Unit, Villejuif. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calcium-Transporting ATPases / metabolism* Calmodulin / pharmacology Environmental Exposure / analysis Erythrocyte Membrane / drug effects, enzymology* Female France / epidemiology Hair / chemistry Humans Infant, Newborn Lead / blood* Lead Poisoning / epidemiology* Male Maternal-Fetal Exchange* Pregnancy Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Calmodulin; 7439-92-1/Lead; EC 3.6.1.8/Calcium-Transporting ATPases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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