Document Detail

Negative-pressure wound therapy: systematic review of randomized controlled trials.
MedLine Citation:
PMID:  21712971     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In negative-pressure wound therapy (NPWT), a wound is covered with an airtight dressing, and negative pressure is applied. This is thought to promote healing. We evaluated NPWT with an updated, systematic review of the literature.
METHODS: We systematically searched the PubMed and Cochrane Library databases for randomized, controlled trials (RCTs) of NPWT for the treatment of acute or chronic wounds. The primary outcome was complete wound closure.
RESULTS: We found reports of 9 RCTs in addition to the 12 covered by earlier IQWiG reviews of this topic. Five of the 9 new trials involved NPWT systems that are not on the market. The frequency of complete wound closure is stated in only 5 of the 9 new reports; a statistically significant effect in favor of NPWT was found in only two trials.The results of 8 of the 9 new trials are hard to interpret, both because of apparent bias and because diverse types of wounds were treated.
CONCLUSION: Although there may be a positive effect of NPWT, we did not find clear evidence that wounds heal any better or worse with NPWT than with conventional treatment. Good RCTs are still needed to evaluate NPWT.
Frank Peinemann; Stefan Sauerland
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-06-03
Journal Detail:
Title:  Deutsches Ärzteblatt international     Volume:  108     ISSN:  1866-0452     ISO Abbreviation:  Dtsch Arztebl Int     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-29     Completed Date:  2012-01-17     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101475967     Medline TA:  Dtsch Arztebl Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  381-9     Citation Subset:  IM    
Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG), Köln.
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MeSH Terms
Bias (Epidemiology)
Endpoint Determination
Negative-Pressure Wound Therapy / methods*
Randomized Controlled Trials as Topic
Wound Healing / physiology

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