Document Detail

Negative pressure wound therapy: a systematic review on effectiveness and safety.
MedLine Citation:
PMID:  18675559     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We reviewed the use of negative pressure wound treatment (NPWT) for problematic wounds. METHODS: A systematic literature review was undertaken to assess the effectiveness and safety of NPWT. Randomized controlled trials (RCTs) assessing NPWT were included. RESULTS: A total of 14 RCTs were included. Trials included patients with pressure wounds (2), post-traumatic wounds (3), diabetic foot ulcers (4) and miscellaneous chronic ulcers (5). In all trials NPWT was at least as effective and in some cases more effective than the control treatment. Most evidence supports the effectiveness of NPWT on chronic leg ulcers and posttraumatic ulcers. NPWT appears to be a safe treatment, and serious adverse events have been rarely reported. Only two trials were classified as high quality studies, whereas the remaining were classified as having poor internal validity. CONCLUSIONS: Reliable evidence on the effectiveness of NPWT is scarce. Tentative evidence indicates that the effectiveness of NPWT is at least as good as or better than current local treatment for wounds. The need for large high-quality randomised studies is apparent.
P Vikatmaa; V Juutilainen; P Kuukasjärvi; A Malmivaara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-08-03
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  36     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-10-02     Revised Date:  2009-06-03    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  438-48     Citation Subset:  IM    
Department of Vascular Surgery, Helsinki University Central Hospital, Meilahti Hospital, Helsinki, Finland.
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MeSH Terms
Chronic Disease
Diabetic Foot / therapy
Leg Injuries / therapy*
Leg Ulcer / therapy*
Negative-Pressure Wound Therapy* / adverse effects
Pressure Ulcer / therapy*
Treatment Outcome
Wound Healing
Comment In:
Eur J Vasc Endovasc Surg. 2009 Jun;37(6):740-1; author reply 741-2   [PMID:  19328731 ]

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