| Negative pressure transients with mechanical heart-valve closure: correlation between in vitro and in vivo results. | |
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MedLine Citation:
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PMID: 9662147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Negative pressure transients (NPT) recorded in a single closing event of mechanical valves in the mitral position in an in vitro setup are compared with data recorded in the left atrium in vivo with the valves implanted in the mitral position in an animal model. The loading at valve closure (dP/dtCL) computed from the in vivo ventricular pressure recording (ranging from 700 to 2300 mm Hg/s) agreed with the magnitudes predicted in our earlier in vitro experiments (750-3000 mm Hg/s). The NPT signals and the corresponding power spectral density plots from the in vivo data were in qualitative agreement with those recorded in vitro. The NPT magnitudes were found to be below the vapor pressure for blood in mechanical valves with rigid occluders suggesting a potential for the valve to cavitate in vivo. Our in vivo results also suggest that the valves with flexible occluders are less likely to cavitate. The correlation of the in vitro and in vivo data also suggests that the flexibility of valve housing used in the in vitro studies is not an important factor in the dynamics of mechanical valve closure in vivo. |
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Authors:
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K B Chandran; E U Dexter; S Aluri; W E Richenbacher |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 26 ISSN: 0090-6964 ISO Abbreviation: Ann Biomed Eng Publication Date: 1998 Jul-Aug |
Date Detail:
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Created Date: 1998-10-01 Completed Date: 1998-10-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 546-56 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City 52242-1527, USA. chandran@icaen.uiowa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomedical Engineering Blood Pressure / physiology Goats Heart Valve Prosthesis* / adverse effects Humans Mitral Valve / physiology Pressure Prosthesis Design |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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