| Negative pressure therapy for complex wounds in patients with sickle-cell disease: a case study. | |
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MedLine Citation:
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PMID: 20729564 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Sickle-cell disease is the most prevalent genetic disease in the Brazilian population. Lower limb ulcers are the most frequent cutaneous complications, affecting 8% to 10% of the patients. These ulcers are usually deep and may take many years to heal. Evidence about the effectiveness of systemic or topical treatment of these wounds is limited, apart from stabilization of the anemia. A 28-year old woman with sickle-cell disease was admitted for treatment of three deep chronic lower leg ulcers. All wounds had tendon exposure and contained firmly adherent fibrin slough. Following surgical debridement and before grafting, the wounds were managed with three different dressings: a rayon and normal saline solution dressing, a calcium alginate dressing covered with gauze, and negative pressure therapy. All three wounds healed successfully and their grafts showed complete integration; only the rayon-dressed wound required a second debridement. The alginate and rayon-dressed wounds recurred after 9 months and required additional skin grafts. Helpful research on managing ulcers in patients with sickle-cell disease is minimal, but the results of this case study suggest that topical treatment modalities may affect outcomes. Research to explore the safety and effectiveness of NPT in patients with sickle-cell wounds is warranted. |
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Authors:
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Andre Oliveira Paggiaro; Viviane Fernandes de Carvalho; Guilherme Henrique Hencklain Fonseca; Allison Doi; Marcus Castro Ferreira |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ostomy/wound management Volume: 56 ISSN: 1943-2720 ISO Abbreviation: Ostomy Wound Manage Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912029 Medline TA: Ostomy Wound Manage Country: United States |
Other Details:
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Languages: eng Pagination: 62-7 Citation Subset: N |
Affiliation:
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Cell Culture and Wound Healing Research Laboratory, Plastic Surgery Division,Faculty of Medicine, University of São Paulo, Brazil; Email:vivianefcarvalho@usp.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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