Document Detail

Negative pressure pulmonary edema following bronchospasm.
MedLine Citation:
PMID:  22045880     Owner:  NLM     Status:  MEDLINE    
Negative pressure pulmonary edema (NPPE) is an important cause of noncardiogenic pulmonary edema but is rarely reported in the setting of bronchospasm. A 43-year-old woman with severe reactive airway disease suffered an episode of severe bronchospasm after endotracheal extubation following an otherwise uneventful general anesthetic. Subsequently, she developed clinical and radiographic signs of pulmonary edema in the absence of other symptoms of acute left-sided heart failure, leading to the diagnosis of noncardiogenic pulmonary edema. She received noninvasive positive pressure ventilation for a few hours, after which her clinical and radiologic signs and symptoms of pulmonary edema were greatly improved. This clinical scenario strongly suggests NPPE. We submit that it is possible to create NPPE by generating highly negative intrathoracic pressures in the setting of severe bronchospasm.
David J Krodel; Edward A Bittner; Raja-Elie E Abdulnour; Robert H Brown; Matthias Eikermann
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  140     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-02     Completed Date:  2011-12-29     Revised Date:  2012-06-13    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1351-4     Citation Subset:  AIM; IM    
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
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MeSH Terms
Bronchial Spasm / complications*,  diagnosis,  therapy
Diagnosis, Differential
Intubation, Intratracheal / adverse effects*
Positive-Pressure Respiration
Pulmonary Edema / diagnosis,  etiology*,  therapy
Respiratory Function Tests
Tomography, X-Ray Computed
Comment In:
Chest. 2012 May;141(5):1365; author reply 1365-6   [PMID:  22553275 ]

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