| Negative predictive value of normal adenosine-stress cardiac MRI in the assessment of coronary artery disease and correlation with semiquantitative perfusion analysis. | |
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MedLine Citation:
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PMID: 20815059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To prospectively determine the negative predictive value of normal adenosine stress cardiac MR (CMR) in routine patients referred for evaluation of coronary artery disease (CAD), predominantly with intermediate to high pretest risk. MATERIALS AND METHODS: Consecutive patients referred for coronary angiography were examined in a 1.5 Tesla whole-body scanner before catheterization. A total of 158 patients with normal CMR on qualitative assessment were included, and semiquantitative perfusion analysis was performed. Significant CAD was regarded as luminal narrowing of >or=70% in coronary angiography. RESULTS: In the 158 study patients, negative predictive value of normal adenosine-stress CMR for significant CAD was 96.2% (for stenosis >or=90%: 98.1%). True-negative and false-negative patients were comparable regarding clinical presentation, risk factors, and CMR findings. Semiquantitative perfusion analysis gave significantly prolonged arrival time index and peak time index in the false-negative group. Using cutoff values >1.8 for arrival time index or >1.2 for peak time index, the CMR negative predictive value increased to 98.7% (for stenosis >or=90%: to 100%). CONCLUSION: The very high negative predictive value for CAD supports CMR-based decision making for the indication to coronary angiography. Semiquantitative perfusion analysis seems promising to identify the small group of CAD patients not detectable by qualitative CMR assessment. |
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Authors:
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Guenter Pilz; Susanne Eierle; Tobias Heer; Markus Klos; Eman Ali; Roland Scheck; Michael Wild; Peter Bernhardt; Berthold Hoefling |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2011-01-10 Revised Date: 2011-02-22 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 615-21 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Clinic Agatharied, Academic Teaching Hospital of the University of Munich, Germany. pilz@khagatharied.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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diagnostic use* Aged Cohort Studies Coronary Angiography / methods Coronary Artery Disease / diagnosis* Exercise Test / methods* False Negative Reactions Female Humans Magnetic Resonance Angiography / methods* Male Middle Aged Myocardial Perfusion Imaging / methods* Predictive Value of Tests Prospective Studies |
| Chemical | |
Reg. No./Substance:
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58-61-7/Adenosine |
| Comments/Corrections | |
Comment In:
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J Magn Reson Imaging. 2011 Feb;33(2):505; author reply 506-7
[PMID:
21274995
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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