Document Detail

Negative effects of ultrafine particle exposure during forced exercise on the expression of Brain-Derived Neurotrophic factor in the hippocampus of rats.
MedLine Citation:
PMID:  22867973     Owner:  NLM     Status:  Publisher    
Exercise improves cognitive function, and brain-derived neurotrophic factor (BDNF) plays a key role in this process. We recently reported that particulate matter (PM) exposure negatively contributed to the exercise-induced increase in human serum BDNF concentration. Furthermore, PM exposure is associated with neuroinflammation and cognitive decline. The aim of this study was to investigate the effect of exposure to ultrafine particles (UFP) during a single bout of forced exercise on the expression of inflammatory (IL1α, IL1β, TNFα, IL6, NOS2, NOS3) and oxidative stress (NFE2L2) related genes, as well as BDNF in the brain of rats. Four groups (n = 6/group) of Wistar rats were exposed for 90 minutes to one of the following exposure regimes: UFP + exercise, UFP + rest, ambient air + exercise, ambient air + rest (control). Hippocampus, olfactory bulb and prefrontal cortex were collected 24 hours after exposure. Gene expression changes were analyzed with Q-PCR. In the condition ambient air + exercise, hippocampal expression of BDNF and NFE2L2 was up-regulated, while the expression of IL1α and NOS3 in the prefrontal cortex and IL1α in the olfactory bulb was down-regulated compared to the control. In contrast, gene expression in the condition UFP + exercise did not differ from the control. In the condition UFP + rest, hippocampal expression of NFE2L2 was down-regulated and there was a trend towards down-regulation of BDNF expression compared to the control. This study shows a negative effect of UFP exposure on the exercise-induced up-regulation of BDNF gene expression in the hippocampus of rats.
I Bos; P De Boever; L Int Panis; S Sarre; R Meeusen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-3
Journal Detail:
Title:  Neuroscience     Volume:  -     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Environmental Risk and Health, Flemish Institute for Technological Research (VITO), Mol, Belgium; Human Physiology & Sports Medicine, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
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