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Negative effects of transfused blood components after hepatectomy for metastatic colorectal cancer.
MedLine Citation:
PMID:  23317602     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
There has been conflicting evidence regarding negative effects of blood transfusion in oncology patients. This study was undertaken to determine any negative effects of specific blood product transfusion after resection of hepatic colorectal metastases (CRM). Retrospective review of patients undergoing hepatectomy for CRM from 1995 to 2009 at a single institution was performed. Specific attention was paid to the effect of blood transfusion within 30 days of operation on overall survival, disease-free survival (DFS), and complications. To mitigate the bias introduced by complications that require blood transfusion to treat, only nonbleeding complications were considered. Complications were analyzed with univariate and multivariate logistic regression. Survival was analyzed according to Kaplan-Meier and Cox proportional hazards. There were 239 patients included in the study. There were 64 (26.8%) receiving a transfusion of any kind with 25.5 per cent getting red cells (PRBCs), 7.11 per cent getting fresh-frozen plasma, and 3.77 per cent getting platelets. Multivariate analysis revealed only PRBC transfusion to be independently associated with nonbleeding complications (odds ratio, 1.980; 95% confidence interval, 1.094 to 3.582; P = 0.0239). There was no significant adverse effect of transfusion with any product on overall or DFS. PRBC transfusion appears to increase the risk of postoperative complications; thus, strategies to minimize blood use may be warranted.
Authors:
Robert M Cannon; Russell E Brown; Charles R St Hill; Eric Dunki-Jacobs; Robert C G Martin; Kelly M McMasters; Charles R Scoggins
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  79     ISSN:  1555-9823     ISO Abbreviation:  Am Surg     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM    
Affiliation:
Department of Surgery, Division of Surgical Oncology, University of Louisville, Louisville, Kentucky, USA.
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