Document Detail

Negative effects of pretransplant body mass index on physical health-related quality of life after lung transplant.
MedLine Citation:
PMID:  23187053     Owner:  NLM     Status:  In-Data-Review    
Background-Although current national data show improved graft and patient survival following lung transplant, the effects of several modifiable preexisting comorbid conditions on health-related quality of life after transplant have not been evaluated. This study examines the effects of 3 comorbid conditions present before lung transplant (reduced bone density, diabetes mellitus, and elevated body mass index) on health-related quality of life after lung transplant.Methods-The Short Form 36 Health Survey was completed by 92 adult recipients at various times after lung transplant (mean, 41 months; range, 1-127 months). Multiple linear regression models that controlled for underlying disease, chronic rejection, and time after transplant tested the independent effects of the 3 pretransplant conditions on posttransplant health-related quality of life.Results-The effects of pretransplant reduced bone density and diabetes mellitus were not statistically significant in these models. However, pretransplant body mass index had a significant negative effect (β = -.29, P = .007) on posttransplant physical health-related quality of life. Additionally, overweight status and obesity exerted comparable independent negative effects (P = .01 and P = .03, respectively) on the physical function scale of the Short-Form 36 Health Survey compared with persons who were underweight or normal weight before transplant.Conclusions-Reevaluation of elevated body mass index before transplant as a risk for reduced physical quality of life after lung transplant should be considered.
Haley M Hoy; Irene D Feurer; Susan Alexander; Jim Loyd; Nancy Wells; C Wright Pinson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in transplantation (Aliso Viejo, Calif.)     Volume:  22     ISSN:  1526-9248     ISO Abbreviation:  Prog Transplant     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909380     Medline TA:  Prog Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-8     Citation Subset:  N    
Vanderbilt Transplant Center, Nashville, Tennessee University of Alabama, Huntsville.
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