Document Detail

Negative and deficit symptoms in schizophrenia do respond to neuroleptics.
MedLine Citation:
PMID:  2863872     Owner:  NLM     Status:  MEDLINE    
Five large-scale placebo-controlled studies are cited to show that, contrary to the contention of Johnstone et al. (1976) and Crow (1980), negative and/or deficit symptoms in schizophrenia do indeed respond to neuroleptic treatment. Further evidence is given that it is the "organic-like" symptoms (visual and olfactory hallucinations, disorientation, and memory deficit) that do not respond to neuroleptics. This would more sensibly reformulate the hypothesis of Johnstone et al. (1976) and Crow (1980) to state that schizophrenic patients with enlarged ventricles tend to show symptoms of organicity and tend not to respond to neuroleptics.
S C Goldberg
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  11     ISSN:  0586-7614     ISO Abbreviation:  Schizophr Bull     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-10     Completed Date:  1985-10-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  453-6     Citation Subset:  IM    
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MeSH Terms
Antipsychotic Agents / therapeutic use*
Arousal / drug effects
Delirium, Dementia, Amnestic, Cognitive Disorders / drug therapy
Interpersonal Relations
Schizophrenia / drug therapy*
Schizophrenia, Disorganized / drug therapy
Schizophrenic Language
Schizophrenic Psychology*
Social Environment
Verbal Behavior / drug effects
Reg. No./Substance:
0/Antipsychotic Agents

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