Document Detail

Negative correlations between parenchymal amyloid and vascular amyloid in hippocampus.
MedLine Citation:
PMID:  3348357     Owner:  NLM     Status:  MEDLINE    
Congo red was used to stain amyloid in 29 blocks of hippocampus from 17 unselected cases of Alzheimer's disease. Green birefringence under polarized light was used for evaluation of the average number of senile plaques and cross-sectional vessel profiles containing amyloid in five fields per slide, at a magnification of X100. Fields were selected that had large numbers of neurofibrillary tangles, also counted on the basis of green birefringence. The vascular involvement by amyloid was expressed as the ratio of amyloid positive to amyloid negative profiles. A negative correlation was found between Congophilic plaques or tangles on the one hand and vascular amyloid content on the other. In other words, cases with large numbers of Congophilic plaques had fewer Congophilic vessels, and vice versa: congophilic plaques = -3 (vessel amyloid) + 2.2, Spearman correlation coefficient, -0.61, P less than 0.01; tangles = -3.7 (vessel amyloid) + 15.6, Spearman correlation coefficient, -0.05, P greater than 0.05. When the slides were reexamined, using only fields with at least one Congophilic vessel, the negative correlation for plaque versus vessel amyloid remained highly significant, whereas that for tangles versus vessel amyloid became highly significant: Congophilic plaques = -1.2 (vessel amyloid) + 2.3, Spearman correlation coefficient, -0.48, P less than 0.01; tangles = -5 (vessel amyloid) + 19, Spearman correlation coefficient, -0.48, P less than 0.01. These data are most compatible with the hypothesis that amyloid is first produced in the parenchyma and is somehow cleared by the vessels. It is least compatible with the hypothesis that the amyloid precursor protein first enters the vessel wall to produce amyloid there, and then moves into the brain to produce amyloid in parenchymal sites.
W I Rosenblum; A Haider
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  130     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-20     Completed Date:  1988-04-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  532-6     Citation Subset:  AIM; IM    
Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / diagnosis,  metabolism*
Amyloid / analysis*
Blood Vessels / metabolism
Congo Red
Hippocampus / blood supply,  metabolism*
Middle Aged
Statistics as Topic
Reg. No./Substance:
0/Amyloid; 573-58-0/Congo Red

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