Document Detail

Negative control of norepinephrine on the thyroid cyclic AMP system.
MedLine Citation:
PMID:  6289914     Owner:  NLM     Status:  MEDLINE    
Negative control on the thyroid cyclic AMP system has been studied. The increase of cyclic AMP levels induced by TSH in dog thyroid slices and its consequent secretion were inhibited by norepinephrine. This effect was different from the previously described activation of cyclic AMP disposal by acetylcholine: it was not calcium-dependent, was observed in the presence of isobutyl methylxanthine and was not inhibited by atropine. The inhibitory action of norepinephrine was abolished by phentolamine but not by L-propranolol. Clonidine and epinephrine also markedly inhibited the elevation of cyclic AMP levels, but phenylephrine did not. The inhibitory effect of norepinephrine and clonidine was abolished by yohimbine but not by prazosin. These results suggest that the effect of adrenergic agents on dog thyroid follicular cells is mediated by alpha 2-receptors. Similar results were obtained on dog thyroid adenylate cyclase activity: norepinephrine diminished the activation of adenylate cyclase induced by TSH, in a sodium-dependent process. This inhibition was abolished by phentolamine and yohimbine, but not by L-propranolol and and prazosin. This shows that the negative alpha 2-adrenergic effect bears directly on adenylate cyclase.
P Cochaux; J van Sande; J E Dumont
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  721     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
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MeSH Terms
Carbachol / pharmacology
Cholera Toxin / pharmacology
Clonidine / pharmacology
Cyclic AMP / metabolism*
Epinephrine / pharmacology
Norepinephrine / pharmacology*
Phentolamine / pharmacology
Phenylephrine / pharmacology
Propranolol / pharmacology
Prostaglandins E / pharmacology
Thyroid Gland / drug effects,  metabolism*
Thyrotropin / pharmacology
Reg. No./Substance:
0/Prostaglandins E; 4205-90-7/Clonidine; 50-60-2/Phentolamine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51-83-2/Carbachol; 525-66-6/Propranolol; 59-42-7/Phenylephrine; 60-92-4/Cyclic AMP; 745-65-3/Alprostadil; 9002-71-5/Thyrotropin; 9012-63-9/Cholera Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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