Document Detail


Negative Pressure Therapy on Primarily Closed Wounds Improves Wound Healing Parameters at 3 Days in a Porcine Model.
MedLine Citation:
PMID:  21886004     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES:: We investigated the role of negative pressure therapy (NPT) in postoperative primary wound treatment and closure. To date, extensive evidence exists demonstrating the benefit of negative pressure dressings in the treatment of open wounds; our experiment tested the hypothesis that negative pressure dressings improve healing of closed (sutured) wounds. METHODS:: A porcine model was used to collect data on the characteristics of closed wounds after 3 days of treatment with NPTs as compared with control dressings. RESULTS:: In six pigs with a total of 56 wounds, load to failure (N/mm) in controls was 0.348 (standard deviation [SD] 0.109) versus NPT at 0.470 (SD, 0.194) with a P value of 0.001; energy to failure (mJ/mm) in controls was 0.85 (SD, 0.378) versus NPT at 1.128 (SD, 0.638) with a P value of 0.035. Blinded grading of clinical wound appearance and cross-sectional hematoma size were also improved at 72 hours. CONCLUSIONS:: NPT dressings applied to surgically closed wounds enhance the healing characteristics of porcine wounds at 3 days. CLINICAL RELEVANCE:: We have observed that primarily closed surgical wounds may benefit from treatment with NPT. The benefit of using NPTs may be most pronounced in situations in which wounds are closed under tension, involve considerable soft tissue trauma, or may be at risk of subdermal hematoma formation.
Authors:
James Meeker; Paul Weinhold; Laurence Dahners
Related Documents :
6693214 - Qrs normalization by ventricular fusion simulating tachycardia dependent left bundle br...
21925024 - A comparative study of changes in the microbiota of apple juice treated by high hydrost...
6825924 - Fibronectin distribution during early chick embryo heart development.
9140184 - Effects of pulsed ultrasound on the frog heart: iii. the radiation force mechanism.
6509034 - Pressure effects on the photocycle of purple membrane.
9086404 - Biomechanics of human common carotid artery and design of novel hybrid textile complian...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-27
Journal Detail:
Title:  Journal of orthopaedic trauma     Volume:  -     ISSN:  1531-2291     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807705     Medline TA:  J Orthop Trauma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Department of Orthopaedics, University of North Carolina School of Medicine, Chapel Hill, NC.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ideal Tibial Intramedullary Nail Insertion Point Varies With Tibial Rotation.
Next Document:  Anatomic Relationships After Instrumentation of the Midshaft Clavicle With 3.5-mm Reconstruction Pla...