Document Detail

Negative Pressure Therapy on Primarily Closed Wounds Improves Wound Healing Parameters at 3 Days in a Porcine Model.
MedLine Citation:
PMID:  21886004     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: We investigated the role of negative pressure therapy (NPT) in postoperative primary wound treatment and closure. To date, extensive evidence exists demonstrating the benefit of negative pressure dressings in the treatment of open wounds; our experiment tested the hypothesis that negative pressure dressings improve healing of closed (sutured) wounds. METHODS:: A porcine model was used to collect data on the characteristics of closed wounds after 3 days of treatment with NPTs as compared with control dressings. RESULTS:: In six pigs with a total of 56 wounds, load to failure (N/mm) in controls was 0.348 (standard deviation [SD] 0.109) versus NPT at 0.470 (SD, 0.194) with a P value of 0.001; energy to failure (mJ/mm) in controls was 0.85 (SD, 0.378) versus NPT at 1.128 (SD, 0.638) with a P value of 0.035. Blinded grading of clinical wound appearance and cross-sectional hematoma size were also improved at 72 hours. CONCLUSIONS:: NPT dressings applied to surgically closed wounds enhance the healing characteristics of porcine wounds at 3 days. CLINICAL RELEVANCE:: We have observed that primarily closed surgical wounds may benefit from treatment with NPT. The benefit of using NPTs may be most pronounced in situations in which wounds are closed under tension, involve considerable soft tissue trauma, or may be at risk of subdermal hematoma formation.
James Meeker; Paul Weinhold; Laurence Dahners
Related Documents :
24474274 - Subfoveal choroidal thickness and cerebrospinal fluid pressure. the beijing eye study 2...
18513714 - Patterning of the heart field in the chick.
6825924 - Fibronectin distribution during early chick embryo heart development.
16880324 - Atrioventricular ring reentry in embryonic mouse hearts.
8591064 - Ambulatory blood pressure monitoring in current clinical practice and research.
16534404 - Home blood pressure self-monitoring: diagnostic performance in white-coat hypertension.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-27
Journal Detail:
Title:  Journal of orthopaedic trauma     Volume:  -     ISSN:  1531-2291     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807705     Medline TA:  J Orthop Trauma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Department of Orthopaedics, University of North Carolina School of Medicine, Chapel Hill, NC.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ideal Tibial Intramedullary Nail Insertion Point Varies With Tibial Rotation.
Next Document:  Anatomic Relationships After Instrumentation of the Midshaft Clavicle With 3.5-mm Reconstruction Pla...