| Negative Amyloid PET Imaging in a Patient With Probable Alzheimer's Disease. | |
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MedLine Citation:
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PMID: 22064086 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Amyloid positron emission tomography (PET) has emerged as an in vivo technique for visualizing the accumulation of fibrillar amyloid-beta (Aβ). Carbon-11 Pittsburgh compound-B (C-11 PIB) has gained widespread acceptance as a standard amyloid PET probe. We report a case of a 53-year-old woman with probable Alzheimer's disease (AD) confirmed by neuropsychological assessment and cerebrospinal fluid analyses. Fluorine-18 fluorodeoxyglucose PET depicted an AD-typical pattern of cortical hypometabolism. Unexpectedly, C-11 PIB PET detected no cortical Aβ depositions. The present case challenges the notion that a negative C-11 PIB scan excludes AD and argues for a comprehensive diagnostic workup. |
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Authors:
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Sabine Hellwig; Michael Hüll; Philipp T Meyer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1120-1 Citation Subset: IM |
Affiliation:
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From the *Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany; †Centre for Geriatric Medicine and Gerontology, University Hospital Freiburg, Freiburg, Germany; and ‡Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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