| Negative Ames tests of epoxide fatty methyl esters derived from hemolysis of linoleic acid hydroperoxides. | |
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MedLine Citation:
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PMID: 6339335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five isomeric epoxyhydroxyene and epoxyoxoene fatty esters derived from hemolytic decomposition of linoleic acid hydroperoxide were tested for mutagenicity by the "Ames' top-agar incorporation method using S-9 mix derived from livers of male rats pretreated with Aroclor 1254. The epoxide fatty esters tested--methyl trans-12,13-epoxy-erythro-11-hydroxy-cis(trans)-9-octadecenoate and methyl trans-12,13-epoxy-threo-11-hydroxy-cis(trans)-9-octadecenoate (each composed of approximately 80% cis-9-ene and 20% trans-9-ene), methyl trans-12,13-epoxy-9-oxo-(trans-10-octadecenoate, methyl trans-12,13-epoxy-9-hydroxy-trans-10-octadecenoate and methyl cis-12,13-epoxy-9-oxo-trans-10-octadecenoate--had structural characteristics similar to certain potent mutagens. However, these esters were not mutagenic in Salmonella typhimurium strains TA100, TA98 or TA1537 at concentrations up to 2000 micrograms/test plate. Under the same test conditions, the methyl ester of hydroperoxy linoleic acid, from which these epoxides were derived, was weakly mutagenic in strain TA100 and possibly also in strain TA98. |
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Authors:
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H W Gardner; C G Crawford; J T MacGregor |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 21 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 1983 Apr |
Date Detail:
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Created Date: 1983-05-27 Completed Date: 1983-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 175-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, High Pressure Liquid Chromatography, Thin Layer Dimethyl Sulfoxide Esters / toxicity Linoleic Acids / toxicity* Lipid Peroxides / toxicity* Magnetic Resonance Spectroscopy Male Mutagenicity Tests Mutagens* Rats Salmonella typhimurium / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Esters; 0/Linoleic Acids; 0/Lipid Peroxides; 0/Mutagens; 25657-09-4/linoleic acid hydroperoxide; 67-68-5/Dimethyl Sulfoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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