Document Detail

Negative Ames tests of epoxide fatty methyl esters derived from hemolysis of linoleic acid hydroperoxides.
MedLine Citation:
PMID:  6339335     Owner:  NLM     Status:  MEDLINE    
Five isomeric epoxyhydroxyene and epoxyoxoene fatty esters derived from hemolytic decomposition of linoleic acid hydroperoxide were tested for mutagenicity by the "Ames' top-agar incorporation method using S-9 mix derived from livers of male rats pretreated with Aroclor 1254. The epoxide fatty esters tested--methyl trans-12,13-epoxy-erythro-11-hydroxy-cis(trans)-9-octadecenoate and methyl trans-12,13-epoxy-threo-11-hydroxy-cis(trans)-9-octadecenoate (each composed of approximately 80% cis-9-ene and 20% trans-9-ene), methyl trans-12,13-epoxy-9-oxo-(trans-10-octadecenoate, methyl trans-12,13-epoxy-9-hydroxy-trans-10-octadecenoate and methyl cis-12,13-epoxy-9-oxo-trans-10-octadecenoate--had structural characteristics similar to certain potent mutagens. However, these esters were not mutagenic in Salmonella typhimurium strains TA100, TA98 or TA1537 at concentrations up to 2000 micrograms/test plate. Under the same test conditions, the methyl ester of hydroperoxy linoleic acid, from which these epoxides were derived, was weakly mutagenic in strain TA100 and possibly also in strain TA98.
H W Gardner; C G Crawford; J T MacGregor
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  21     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  IM    
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MeSH Terms
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Dimethyl Sulfoxide
Esters / toxicity
Linoleic Acids / toxicity*
Lipid Peroxides / toxicity*
Magnetic Resonance Spectroscopy
Mutagenicity Tests
Salmonella typhimurium / drug effects
Reg. No./Substance:
0/Esters; 0/Linoleic Acids; 0/Lipid Peroxides; 0/Mutagens; 25657-09-4/linoleic acid hydroperoxide; 67-68-5/Dimethyl Sulfoxide

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