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Negativation of Type 1 Diabetes Associated Autoantibodies to Glutamic Acid Decarboxylase and Insulin in Children Treated with Oral Calcitriol.
MedLine Citation:
PMID:  23302101     Owner:  NLM     Status:  Publisher    
BACKROUND: With the recent knowledge of the possible involvement of 1,25-dihydroxyvitamin D in the pathogenesis of Type 1 Diabetes (T1D) and the results of its administration in animal models, we conducted a clinical trial by treating high-risk children, positive in autoantibodies for T1D, with oral calcitriol. METHODS: This prospective trial included 12 children aged 1.5-13 yrs at presentation, who were investigated for the potential risk for T1D because of the already diagnosed association of celiac disease and autoimmune thyroiditis (4 girls), autoimmune thyroiditis at a very young age (2 girls, 2 boys), diagnosis of T1D in their siblings (2 boys) and impaired glucose tolerance (1 boy, 1 girl). Serum levels of autoantibodies (ICA, anti-GAD65, IAA, anti-IA2) and calcium metabolism (Ca, P, PTH, ALP, total 25(OH)vitamin D and Ca/Cr in 2-hr morning urine sample) were evaluated prior and at 6 month intervals after initiating 0.25 μg daily calcitriol for 1 to 3 yrs. RESULTS: In all children included persistent negativation of the anti-GAD65 (7 children) and IAA autoantibodies (6 children) was observed within 0.4-2.1 yrs. Of the two children with IGT the boy proved to have MODY 2 and the girl normalized her glycaemic profile. CONCLUSIONS: Despite the small number of subjects and the absence of a control group, 0.25 μg of daily calcitriol is effective in negativation of the anti-GAD65 and IAA autoantibodies at a median time of 6 months. This simple, safe and of low cost strategy may prove effective in prevention of T1D in the future. © 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Dimitrios T Papadimitriou; Chrisanthi Marakaki; Andreas Fretzayas; Polyxeni Nicolaidou; Anastasios Papadimitriou
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Journal of diabetes     Volume:  -     ISSN:  1753-0407     ISO Abbreviation:  J Diabetes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504326     Medline TA:  J Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Third Department of Pediatrics, "Attikon" University Hospital, Athens, Greece.
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