Document Detail

Nefazodone alters NPY immunostaining in rat arcuate-paraventricular projection without changes in food intake and body weight.
MedLine Citation:
PMID:  12385598     Owner:  NLM     Status:  MEDLINE    
Nefazodone is an antidepressant drug that inhibits serotonin and noradrenaline reuptake. The aim of the present work was to study the effects of nefazodone on food intake, body weight, adiposity and hypothalamic NPY immunostaining in rats. For this purpose, male Sprague-Dawley rats (3-month-old) were administered with nefazodone (20 mg/kg; i.p) daily for two weeks. The control group was given 0.9% NaCl solution. Hypothalamic arcuate, paraventricular, periventricular, supraoptic and suprachiasmatic nuclei and the lateral hypothalamic area were immunostained for NPY. Chronic nefazodone administration in rats did not modify food intake, body weight and adipose depot size (subcutaneous, perirenal and epididymal white adipose tissues, and interscapular brown adipose tissue). However, a significant decrease in paraventricular NPY immunostaining was found in the nefazodone group compared with the control group. No changes in other hypothalamic regions such as arcuate, periventricular, supraoptic and suprachiasmatic nuclei, and lateral and medial preoptic areas were observed. Because nefazodone is an alpha1-adrenoceptor antagonist, it can be proposed that the expected decrease in food intake after nefazodone administration, due to its effects on NPY arcuate-paraventricular projection, could be masked by the opposite orexigenic effect of alpha1-adrenoceptor blockade.
G Saracíbar; A Casado; V M Rodríguez; M P Portillo; M T Macarulla; L C Abecia; Enrique Echevarría; L Casis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  5     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-18     Completed Date:  2003-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  353-8     Citation Subset:  IM    
Department of Physiology, School of Pharmacy, University of the Basque Country, Vitoria, Spain.
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MeSH Terms
Adipose Tissue / drug effects,  physiology
Adipose Tissue, Brown / drug effects,  physiology
Antidepressive Agents, Second-Generation / pharmacology*
Arcuate Nucleus / drug effects,  metabolism*
Body Weight / drug effects,  physiology*
Energy Intake
Neuropeptide Y / metabolism*
Paraventricular Hypothalamic Nucleus / drug effects,  metabolism*
Rats, Sprague-Dawley
Triazoles / pharmacology*
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Neuropeptide Y; 0/Triazoles; 83366-66-9/nefazodone

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