| Nef performance in Macrophages: the Master Orchestrator of Viral Persistence and Spread. | |
| | |
MedLine Citation:
|
PMID: 22103834 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Following transmission of human immunodeficiency virus (HIV) into a new host, cells of the monocyte/macrophage lineage play a central role in host invasion and viral replication. In particular, macrophages survive infection and support long-standing viral replication, contributing to viral persistence within the host and representing a viral reservoir in vivo. On the other hand, HIV Nef protein is a small though versatile molecule that plays an unquestioned key role in viral pathogenesis. In macrophages, Nef is able to modulate cell surface receptor expression, to intersect intracellular signaling pathways and to augment the release of pro-inflammatory and chemotactic molecules. In addition, Nef can alter macrophage phagocytic capacity, autophagy machinery and metabolism. Altogether, these Nef activities support viral replication and persistence in this cell type while at the same time favor viral dissemination. Here, we will review the newest findings describing how monocytes/macrophages natural pathways are altered by Nef protein, highlighting how viral and host biology are perturbed in consequence. |
| | |
Authors:
|
Yanina Ghiglione; Gabriela Turk |
Related Documents
:
|
11475134 - Can we influence fibrosis in crohn's disease? 10625324 - Oral tolerance: a new tool for the treatment of gastrointestinal inflammatory disorders... 17343084 - Apoptosis as a therapeutic paradigm in inflammatory bowel diseases. 19103524 - Nod2 engagement induces proinflammatory cytokine production, but not apoptosis, in leuk... 18285404 - Lack of ccr5 on dendritic cells promotes a proinflammatory environment in submandibular... 3263104 - Effect of interleukin 2 on kupffer cell activation. interleukin 2 primes and activates ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-18 |
Journal Detail:
|
Title: Current HIV research Volume: - ISSN: 1873-4251 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101156990 Medline TA: Curr HIV Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
National Reference Center for AIDS, University of Buenos Aires, Paraguay 2155 Piso 11, C1121ABG - Buenos Aires, Argentina. gturk@fmed.uba.ar. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.
Next Document: Tetherin Antagonism by Primate Lentiviral Nef Proteins.