Document Detail

Needle in a haystack-parathyroid gland in a 10-day old infant: a case report and literature review.
MedLine Citation:
PMID:  22389784     Owner:  NLM     Status:  In-Data-Review    
Neonatal severe primary hyperparathyroidism (NSPHT) is a rare autosomal recessive disorder of calcium homeostasis. It presents shortly after birth and is characterized by striking hyperparathyroidism, marked hypercalcemia, and hyperparathyroid bone disease. It is caused by mutations of the calcium-sensing receptor (CASR), the ionized calcium sensor for the parathyroid cells, the parafollicular thyroid C cells, and the kidney epithelium, as well as cells in bone and intestine. Without early intervention, which frequently requires surgical removal of the hyperplastic parathyroids, the patients often succumb to complications of hypercalcemia and respiratory failure. Finding the parathyroid gland in small neonates is not an easy task. Here we report on a patient with neonatal hyperparathyroidism who was treated by total parathyroidectomy and discuss the various ways of helping to find the parathyroid glands during surgery at this young age.
Adel Ismail; Tariq O Abbas; Fawziya Al-Khalaf
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Publication Detail:
Type:  Journal Article     Date:  2011-08-03
Journal Detail:
Title:  ISRN pediatrics     Volume:  2011     ISSN:  2090-4703     ISO Abbreviation:  ISRN Pediatr     Publication Date:  2011  
Date Detail:
Created Date:  2012-03-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101568077     Medline TA:  ISRN Pediatr     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  678070     Citation Subset:  -    
Pediatric Surgery Department, Hamad General Hospital, P.O. Box 3050, Doha, Qatar.
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