Document Detail


Need for vaccination of susceptible food handlers against hepatitis A in Taiwan.
MedLine Citation:
PMID:  11155755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: With the improvement in the socioeconomic situation and general hygiene standards in Taiwan, the prevalence of antibodies to the hepatitis A virus (anti-HAV) in the general population has declined markedly in recent years. To avoid food-borne outbreaks of HAV infection caused by susceptible food handlers in Taiwan, we investigated the seroprevalence of anti-HAV among the target population and also evaluated the immunogenicity and reactogenicity of the inactivated hepatitis A vaccine in this study group. METHODS: Two hundred and forty-four food handlers employed in four restaurants at Taipei Veterans General Hospital participated in the anti-HAV serologic screening program in July 1997. Of them, 48 susceptible food handlers received three doses of 720 enzyme-linked immunosorbent units of inactivated hepatitis A vaccine at 0, 1 and 6 months. RESULTS: Of the 244 food handlers who underwent anti-HAV serologic screening, 169 (69.3%) were anti-HAV positive. The seroprevalence of anti-HAV was related to age: 91.5% of food handlers over 30 years of age were positive for anti-HAV but only 22.8% of food handlers younger than 30 were anti-HAV positive. Anti-HAV response was observed in all vaccinees after a booster vaccination at month 6. The response persisted to 1 year. The side-effects of the vaccinations were minimal. CONCLUSIONS: Susceptible food handlers should receive hepatitis A vaccination. Hepatitis A vaccine is safe and immunogenic in this target population.
Authors:
M I Yu; S D Lee; R H Lu; C Y Chan; Y J Wang; F Y Chang; K J Lo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zhonghua yi xue za zhi = Chinese medical journal; Free China ed     Volume:  63     ISSN:  0578-1337     ISO Abbreviation:  Zhonghua Yi Xue Za Zhi (Taipei)     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-11     Completed Date:  2001-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0005327     Medline TA:  Zhonghua Yi Xue Za Zhi (Taipei)     Country:  China (Republic: 1949- )    
Other Details:
Languages:  eng     Pagination:  798-803     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Disease Susceptibility
Female
Food Contamination
Food Handling*
Health Services Needs and Demand
Hepatitis A / epidemiology,  prevention & control*
Hepatitis A Vaccines*
Humans
Male
Middle Aged
Seroepidemiologic Studies
Taiwan / epidemiology
Vaccination*
Chemical
Reg. No./Substance:
0/Hepatitis A Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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