Document Detail

Nedocromil sodium is more potent than sodium cromoglycate against AMP-induced bronchoconstriction in atopic asthmatic subjects.
MedLine Citation:
PMID:  2544248     Owner:  NLM     Status:  MEDLINE    
Nedocromil sodium is a new chemical entity which shows similar properties to sodium cromoglycate (SCG) and in addition exhibits a preferential activity in stabilizing mucosal mast cells. We have compared the effect of inhalation of nebulized placebo, SCG and nedocromil sodium on the bronchoconstrictor response to inhaled adenosine monophosphate (AMP) in eight atopic asthmatic subjects aged 25 yr (range 21-32 yr). The geometric mean provocation doses of AMP required to produce a 20% decrease in FEV1 (PD20FEV1) and a 40% decrease in Vmax30 (PD40 Vmax30) following placebo were 4.9 (0.3-14.2) and 1.8 (0.1-8.4) mumol respectively. Prior inhalation of both SCG and nedocromil sodium significantly inhibited the bronchoconstrictor response to AMP with PD20FEV1s of 36.6 (4.0-132.7) and 134 (12.4-560), and PD40 Vmax30 values of 20.5 (1.4-110) and 101.6 (5-560) mumol respectively (P less than 0.001). Nedocromil sodium was 3.9 (FEV1) and 8.0 (Vmax30) times more potent than SCG (P less than 0.001). In conclusion, both drugs inhibit the bronchoconstrictor response to inhaled AMP, and nedocromil is at least 4-8 times more potent than SCG.
R Richards; G D Phillips; S T Holgate
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  19     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-08-03     Completed Date:  1989-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  285-91     Citation Subset:  IM    
Medicine I, Level D, Centre Block, Southampton General Hospital, U.K.
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MeSH Terms
Adenosine Monophosphate / diagnostic use
Administration, Inhalation
Asthma / chemically induced,  drug therapy*
Bronchial Provocation Tests
Cromolyn Sodium / administration & dosage,  therapeutic use*
Forced Expiratory Volume
Methacholine Compounds / administration & dosage
Quinolones / administration & dosage,  therapeutic use*
Skin Tests
Reg. No./Substance:
0/Methacholine Compounds; 0/Quinolones; 15826-37-6/Cromolyn Sodium; 61-19-8/Adenosine Monophosphate; 69049-73-6/Nedocromil

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