Document Detail


Nedocromil sodium is more effective than cromolyn sodium for the treatment of chronic reversible obstructive airway disease.
MedLine Citation:
PMID:  8393398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a multicenter, double-blind, group comparative trial, the efficacy of nedocromil sodium (nedocromil, 4 mg, four times daily [qid]), cromolyn sodium (2 mg, qid), and placebo was compared in patients receiving inhaled beta 2-agonists and inhaled corticosteroids for the treatment of chronic reversible obstructive airway disease. After a 2-week baseline period, 132 patients (8 centers) between the ages of 20 and 75 years entered a 4-week run-in period in which the dose of inhaled corticosteroid was reduced by 50 percent. During the run-in phase, deterioration of symptoms (total symptom score) by ten points qualified patients to enter the 6-week drug trial period. Patients in the nedocromil treatment group showed the most robust and consistent improvements over placebo and cromolyn sodium for all daily dairy variables. Statistically significant improvements over placebo were noted for both active treatment groups for daytime, nighttime, and total symptom score. Symptom scores for nedocromil were statistically significantly improved over both cromolyn sodium and placebo for both daytime and nighttime asthma. Patients treated with nedocromil also demonstrated a significant reduction in the use of nighttime as needed (prn) beta 2-agonists as compared with either the placebo- or cromolyn sodium-treated groups. Only nedocromil-treated patients demonstrated a statistically significant improvement in morning peak expiratory flow rate (PEFR) as compared with placebo. Both nedocromil and cromolyn sodium groups demonstrated statistically significant improvements in afternoon and evening PEFRs. Collectively, the improvements in nighttime symptoms, decreased bronchodilator use, and improved morning PEFR show that patients treated with nedocromil had improved nocturnal symptoms. Pulmonary function tests (FEV1, FVC, PEFR) demonstrated no statistically significant differences between the two active treatments, although trends favored nedocromil for both FEV1 and PEFR. Although symptoms improved in patients treated with cromolyn sodium, the level of symptom control was less than that achieved by nedocromil. As compared with baseline control (regular dose of inhaled steroids), patients treated with nedocromil plus the 50 percent reduced dosage of inhaled corticosteroid consistently demonstrated comparable or better symptom control. Although both active drugs reduced symptoms, nedocromil proved to be more effective than cromolyn sodium for treatment of reversible obstructive airway disease in patients normally well maintained on regimens of low to moderate doses of inhaled corticosteroids.
Authors:
S Lal; P D Dorow; K K Venho; S S Chatterjee
Related Documents :
2008788 - Corticosteroids for acute, severe asthma.
11799368 - Comparative efficacy and anti-inflammatory profile of once-daily therapy with leukotrie...
8102918 - Effect on airway responsiveness of six weeks treatment with salmeterol.
19351238 - Ciclesonide therapy in asthma: a potential effect on small airway inflammation?
22211348 - Adaptation of the patient feedback survey at a community treatment setting.
22965258 - Validation of the korean version of the oxford knee score in patients undergoing total ...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  104     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-02     Completed Date:  1993-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  438-47     Citation Subset:  AIM; IM    
Affiliation:
Bury General Hospital, England.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Asthma / drug therapy*,  physiopathology
Cromolyn Sodium / adverse effects,  therapeutic use*
Double-Blind Method
Female
Forced Expiratory Volume / drug effects
Humans
Male
Middle Aged
Nedocromil
Peak Expiratory Flow Rate / drug effects
Quinolones / adverse effects,  therapeutic use*
Vital Capacity / drug effects
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Quinolones; 15826-37-6/Cromolyn Sodium; 69049-73-6/Nedocromil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Detection and sequencing of p53 gene mutations in bronchial biopsy samples in patients with lung can...
Next Document:  Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic ...