Document Detail

Nedocromil sodium inhibits the airway response to hyperosmolar challenge in patients with asthma.
MedLine Citation:
PMID:  1359818     Owner:  NLM     Status:  MEDLINE    
We studied 16 asthmatic subjects sensitive to changes in airway osmolarity to determine whether nedocromil sodium has any effect on airway narrowing caused by hypertonic saline challenges. Nedocromil sodium (10 mg) or its vehicle was inhaled 10 min before a challenge with ultrasonically nebulized 4.5% NaCl. FEV1 was measured before challenge and 1 min after each challenge period of 0.5, 1, 2, 4, 8, 8 and 8 min. The challenge was stopped when there was a 20% fall in FEV1 from baseline or after the final challenge period. We measured airway sensitivity, that is, the provoking dose of 4.5% NaCl required to induce a 20% reduction in FEV1 (PD20FEV1) and calculated the fold difference in PD20FEV1 after the intervention. After inhaling nedocromil sodium there was a 3.95-fold improvement in PD20 (p < 0.001) when compared with the vehicle day. After pretreatment with nedocromil sodium two of the 16 subjects were completely protected against 4.5% NaCl challenge, and six developed a plateau in their response. We conclude that nedocromil sodium is effective in reducing airway narrowing in response to 4.5% NaCl challenge in asthmatic subjects, and it appears to be unique in its ability to produce a plateau in response to acute administration of a drug before a bronchial challenge.
L T Rodwell; S D Anderson; J Du Toit; J P Seale
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  146     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-15     Completed Date:  1992-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1149-55     Citation Subset:  AIM; IM    
Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
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MeSH Terms
Administration, Inhalation
Adrenal Cortex Hormones / therapeutic use
Adrenergic beta-Agonists / therapeutic use
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  pharmacology,  therapeutic use*
Asthma / diagnosis,  drug therapy*,  physiopathology
Beclomethasone / administration & dosage,  therapeutic use
Body Height
Bronchial Provocation Tests
Confidence Intervals
Dose-Response Relationship, Drug
Double-Blind Method
Drug Therapy, Combination
Forced Expiratory Volume / drug effects*
Middle Aged
Quinolones / administration & dosage,  pharmacology,  therapeutic use*
Saline Solution, Hypertonic / administration & dosage,  diagnostic use*
Sensitivity and Specificity
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Adrenergic beta-Agonists; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Quinolones; 0/Saline Solution, Hypertonic; 4419-39-0/Beclomethasone; 69049-73-6/Nedocromil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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