| Nedocromil sodium and the immune response. | |
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MedLine Citation:
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PMID: 7912148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chromones are frequently employed in the treatment of allergic rhinoconjunctivitis and asthma. Following our recent investigations concerning the influence of some antiallergic drugs, such as cromoglycate sodium, steroids, oxatomide and ketotifen (H1 antihistamines), and theophylline, on the immune response, in the present study we analyzed the in vitro effects of a new chromone derivative, nedocromil, on the immune response. To this end, the proliferation of peripheral mononuclear cells (PMNCs) induced by mitogen (PHA) and by CD3, CD2 or CD28 monoclonal antibodies (MAbs) has been studied. Since the effects of nedocromil on immunological parameters are achieved at 10(-7) mol/l, in the experiments herein reported the drug was tested in the cultures at concentrations of 10(-8), 10(-7) and 10(-6) mol/l. Furthermore, the effect of nedocromil was evaluated on the surface expression of the following markers expressed by PMNCs upon activation: ICAM-1 (CD54), LFA-1 and alpha 1-acid glycoprotein (alpha 1-AGP). The results of the present investigation showed no effect of nedocromil on these immunological parameters. These data acquire clinical relevance when related to previous reports showing a depression of the immunological response exerted by other compounds, such as ketotifen, theophylline and steroids. |
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Authors:
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G Ciprandi; S Buscaglia; M Albano; C Bertolini; T Truffelli; A Catrullo; A Scordamaglia; G W Canonica |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología Volume: 3 ISSN: 1018-9068 ISO Abbreviation: J Investig Allergol Clin Immunol Publication Date: 1993 Nov-Dec |
Date Detail:
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Created Date: 1994-07-25 Completed Date: 1994-07-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107858 Medline TA: J Investig Allergol Clin Immunol Country: SPAIN |
Other Details:
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Languages: eng Pagination: 311-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine-DI.M.I., University of Genoa, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, Surface / biosynthesis Cell Adhesion Molecules / biosynthesis Female Humans Intercellular Adhesion Molecule-1 Leukocytes, Mononuclear / drug effects, immunology, metabolism Lymphocyte Activation / drug effects* Lymphocyte Function-Associated Antigen-1 / biosynthesis Male Nedocromil / pharmacology*, therapeutic use Orosomucoid / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Surface; 0/Cell Adhesion Molecules; 0/Lymphocyte Function-Associated Antigen-1; 0/Orosomucoid; 126547-89-5/Intercellular Adhesion Molecule-1; 69049-73-6/Nedocromil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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