Document Detail

Nectin4 is an epithelial cell receptor for canine distemper virus and involved in neurovirulence.
MedLine Citation:
PMID:  22761370     Owner:  NLM     Status:  MEDLINE    
Canine distemper virus (CDV) uses signaling lymphocyte activation molecule (SLAM), expressed on immune cells, as a receptor. However, epithelial and neural cells are also affected by CDV in vivo. Wild-type CDV strains showed efficient replication with syncytia in Vero cells expressing dog nectin4, and the infection was blocked by an anti-nectin4 antibody. In dogs with distemper, CDV antigen was preferentially detected in nectin4-positive neurons and epithelial cells, suggesting that nectin4 is an epithelial cell receptor for CDV and also involved in its neurovirulence.
Watanyoo Pratakpiriya; Fumio Seki; Noriyuki Otsuki; Kouji Sakai; Hideo Fukuhara; Hiromu Katamoto; Takuya Hirai; Katsumi Maenaka; Somporn Techangamsuwan; Nguyen Thi Lan; Makoto Takeda; Ryoji Yamaguchi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-03
Journal Detail:
Title:  Journal of virology     Volume:  86     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-27     Completed Date:  2012-11-21     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10207-10     Citation Subset:  IM    
Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
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MeSH Terms
Antigens, Viral / metabolism
Cell Adhesion Molecules / physiology*
Cercopithecus aethiops
Distemper / virology
Distemper Virus, Canine / immunology,  pathogenicity*,  physiology*
Host-Pathogen Interactions / physiology
Neurons / virology
Receptors, Virus / physiology*
Vero Cells
Virulence / physiology
Reg. No./Substance:
0/Antigens, Viral; 0/Cell Adhesion Molecules; 0/Receptors, Virus; 0/nectins

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