Document Detail


Necrotizing external otitis: aminoglycoside and beta-lactam antibiotic treatment combined with surgical treatment.
MedLine Citation:
PMID:  9222636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Necrotizing external otitis is a life-threatening condition that still causes therapeutic problems. A retrospective analysis of 22 patients who were all treated with a short standard course of aminoglycoside and beta-lactam antibiotic with through local debridement was carried out; 50% (11/22) had diabetes mellitus, and all had a positive culture of Pseudomonas aeruginosa. The frequency of recurrence was 14% (3/22), and 95% (21/22) were eventually cured. The treatment course lasted 17 days on average. Side effects caused by the drug treatment were seen in 14% (3/22), but they were mild and transient consisting of a reversible increase of the serum creatinine level. It was concluded that the treatment was short, efficient, safe, and as successful as treatment with quinolones or third-generation cephalosporins which has been reported during the past years. In our opinion, therefore, these drugs should be reserved for cases of treatment failure, development of resistance, or side effects.
Authors:
H B Pedersen; J Rosborg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical otolaryngology and allied sciences     Volume:  22     ISSN:  0307-7772     ISO Abbreviation:  Clin Otolaryngol Allied Sci     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-25     Completed Date:  1997-08-25     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7701793     Medline TA:  Clin Otolaryngol Allied Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  271-4     Citation Subset:  IM    
Affiliation:
Ear, Nose and Throat Department, Aalborg Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aminoglycosides
Anti-Bacterial Agents / therapeutic use*
Debridement
Diabetes Complications
Drug Administration Schedule
Drug Therapy, Combination / therapeutic use*
Female
Follow-Up Studies
Humans
Male
Necrosis
Otitis Externa / complications,  drug therapy*,  surgery*
Pseudomonas Infections / complications,  drug therapy*,  surgery*
Recurrence
Retrospective Studies
Time Factors
beta-Lactams
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/beta-Lactams

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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