Document Detail

Necrotizing external otitis: aminoglycoside and beta-lactam antibiotic treatment combined with surgical treatment.
MedLine Citation:
PMID:  9222636     Owner:  NLM     Status:  MEDLINE    
Necrotizing external otitis is a life-threatening condition that still causes therapeutic problems. A retrospective analysis of 22 patients who were all treated with a short standard course of aminoglycoside and beta-lactam antibiotic with through local debridement was carried out; 50% (11/22) had diabetes mellitus, and all had a positive culture of Pseudomonas aeruginosa. The frequency of recurrence was 14% (3/22), and 95% (21/22) were eventually cured. The treatment course lasted 17 days on average. Side effects caused by the drug treatment were seen in 14% (3/22), but they were mild and transient consisting of a reversible increase of the serum creatinine level. It was concluded that the treatment was short, efficient, safe, and as successful as treatment with quinolones or third-generation cephalosporins which has been reported during the past years. In our opinion, therefore, these drugs should be reserved for cases of treatment failure, development of resistance, or side effects.
H B Pedersen; J Rosborg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical otolaryngology and allied sciences     Volume:  22     ISSN:  0307-7772     ISO Abbreviation:  Clin Otolaryngol Allied Sci     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-25     Completed Date:  1997-08-25     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7701793     Medline TA:  Clin Otolaryngol Allied Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  271-4     Citation Subset:  IM    
Ear, Nose and Throat Department, Aalborg Hospital, Denmark.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Diabetes Complications
Drug Administration Schedule
Drug Therapy, Combination / therapeutic use*
Follow-Up Studies
Otitis Externa / complications,  drug therapy*,  surgery*
Pseudomonas Infections / complications,  drug therapy*,  surgery*
Retrospective Studies
Time Factors
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/beta-Lactams

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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