Document Detail

Necrotizing enterocolitis.
MedLine Citation:
PMID:  803385     Owner:  NLM     Status:  MEDLINE    
The clinical course of 54 patients with necrotizing enterocolitis has been compared to a matched group of 98 control patients. On the day of life that NEC occurred, all 54 NEC patients and 63% of controls were receiving standard formula feedings, both at 80/cal/kg/day. Stool cultures at the time revealed a significantly increased frequency of Klebsiella in NEC as compared to control patients. Our data suggest that the combined presence of certain intestinal bacteria and enteric feedings, perhaps requiring a background of mucosal ischemia, may be of etiologic significance in the development of NEC and its radiologic hallmark, pneumatosis intestinalis.
I D Frantz; P L'heureux; R R Engel; C E Hunt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  86     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-05-06     Completed Date:  1975-05-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-63     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight
Disseminated Intravascular Coagulation / etiology
Enterobacteriaceae / isolation & purification
Enterocolitis, Pseudomembranous* / complications,  etiology,  radiography,  therapy
Feces / microbiology
Gestational Age
Infant Food
Infant, Newborn
Infant, Newborn, Diseases* / etiology
Infant, Premature, Diseases / etiology
Intestines / microbiology
Klebsiella / isolation & purification
Necrosis* / etiology
Parenteral Nutrition / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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