Document Detail

Necrotizing enterocolitis and the role of anemia of prematurity.
MedLine Citation:
PMID:  22818548     Owner:  NLM     Status:  In-Data-Review    
Necrotizing enterocolitis (NEC) is one of the most common surgical diseases of preterm infants, with significant short- and long-term morbidity and mortality. Although the etiology of NEC remains elusive, multiple factors adversely affecting the intestinal mucosal integrity of preterm infants are known to be associated with NEC. Anemia and red blood cell (RBC) transfusion-related gut injury have been shown to have strong correlation with NEC. Anemia potentially compromises mucosal integrity with subsequent poor healing, and this injury may be augmented by yet unknown factors associated with RBC transfusions. Although convincing evidence is lacking, there is a need for guidelines to keep the hematocrit within clinically and physiologically relevant limits by appropriate interventions. Further investigations need to focus on assessing the interplay between anemia, chronically hypoxemic/hypoperfused intestines, and early iron therapy or other pharmacologic approaches for prevention/treatment of anemia and RBC transfusions.
Rachana Singh; Bhavesh L Shah; Ivan D Frantz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in perinatology     Volume:  36     ISSN:  1558-075X     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Division of Newborn Medicine, Department of Pediatrics, Baystate Children's Hospital, The Western Campus of Tufts University School of Medicine, Springfield, MA.
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